Online Monitoring And Portable Analytical System With Cmos Sensor And Microfluidic Technology For Cell Cultivation Applications

• doi: 10.1109/SOPO.2010.5504420
• title: Online Monitoring and Portable Analytical System with CMOS Sensor and Microfluidic Technology for Cell Cultivation Applications
• publisher: IEEE
• isbn: 978-1-4244-4964-4
• issn: 2156-8480
• partnum: 10EX3968
• rank: 3186
• access_type: LOCKED
• content_type: Conferences
• abstract: This paper presents about the design and fabrication of a cost effective and portable system for real time monitoring and data analysis of cell cultivation applications based on CMOS sensor and microfluidic technology. The digital CMOS sensor has 2-Mpixel resolution and output digital data that is designed and fabricated on the 0.18um CMOS image process. The Chip has integrated with low noise 2 shared 2.25T pinned photodiode active pixel, noise reduction circuit, analog to digital converter and timing control circuits. The module based on the 2-Mpixel CMOS sensor has two focuses that can capture the image of the business card so that the monitoring system is so compact and low power. In this paper, one microfluidic product has been fabricated based on the MEMS process that applies for cell cultivation. The online monitoring and analytical system uses CMOS image sensor to capture the image of the microfluidic applications and a field programmable gate array (FPGA) chip to process the captured image. The final image can be displayed in the monitor or be sent to computer to be stored. This technique can be utilized in monitoring the cell size lying on the pixel size of CMOS sensor. In this paper, the monitoring cell size is large than 2.8um for the pixel size of CMOS sensor is 2.8um. The advantages of this system not only provide miniaturization and minimum cost, but also offer many advantages over conventional laboratory experiments, such as low energy LED light, parallel and fast microfluidic chip, high resolution CMOS sensor, fast and accurate test, low cost and consumption, etc.
• article_number: 5504420
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=5504420
• html_url: https://ieeexplore.ieee.org/document/5504420/
• abstract_url: https://ieeexplore.ieee.org/document/5504420/
• publication_title: 2010 Symposium on Photonics and Optoelectronics
• conference_location: Chengdu, China
• conference_dates: 19-21 June 2010
• publication_number: 5503651
• is_number: 5503985
• publication_year: 2010
• publication_date: 19-21 June 2010
• start_page: 1
• end_page: 4
• citing_paper_count: 0
• citing_patent_count: 0
• download_count: 318
• insert_date: 20100708
• index_terms:
  • ieee_terms:
    • Sensor systems and applications
    • Microfluidics
    • CMOS technology
    • CMOS image sensors
    • Computerized monitoring
    • Costs
    • CMOS process
    • Circuits
    • Sensor systems
    • Field programmable gate arrays
  • dynamic_index_terms:
    • Analysis System
    • Portable System
    • Sensor Technology
    • Online Monitoring
    • Microfluidic Technology
    • Low Cost
    • Image Processing
    • Light-emitting Diodes
    • LED Light
    • Light Emission
    • LEDs
    • Test Accuracy
    • Real-time Data
    • Advanced Systems
    • Promoter System
    • Low Noise
    • Analog-to-digital Converter
    • Analog-to-digital
    • Digital-to-analog Converter
    • Image Sensor
    • Camera Sensor
    • Microfluidic Chip
    • Lab-on-chip
    • Lab-on-a-chip
    • Image Capture
    • Gate Array
    • Sensor Size
    • System-on-chip
    • Atomic Force Microscopy
    • Optical Lens
    • Optical Lenses
    • Printed Circuit Board
    • High Cost
    • Optical Force
    • Photomultiplier Tube
    • Power Consumption
    • Digital Signal Processing
    • Imaging Data
• isbn_formats:
  • format: CD, value: 978-1-4244-4964-4, isbnType: New-2005
  • format: Print ISBN, value: 978-1-4244-4963-7, isbnType: New-2005
• authors:
  • Author Name: XiangLiang Jin
    Affiliation: Faculty of Materials, Optoelectronics and Physics, Xiangtan University, Xiangtan, China
    Author URL: https://ieeexplore.ieee.org/author/37086130160
    ID: 37086130160
    Order: 1
    Author Affiliations:
    • Faculty of Materials, Optoelectronics and Physics, Xiangtan University, Xiangtan, China
    • Faculty of Engineering, University of Western Ontario, London, Canada
  • Author Name: Zhibi Liu
    Affiliation: Superpix Micro Technology Company, Beijing, China
    Author URL: https://ieeexplore.ieee.org/author/37533654100
    ID: 37533654100
    Order: 2
    Author Affiliations:
    • Superpix Micro Technology Company, Beijing, China
  • Author Name: Tingjie Li
    Affiliation: Faculty of Engineering, University of Western Ontario, London, Canada
    Author URL: https://ieeexplore.ieee.org/author/37539274300
    ID: 37539274300
    Order: 3
    Author Affiliations:
    • Faculty of Engineering, University of Western Ontario, London, Canada
  • Author Name: Qiuquan Guo
    Affiliation: Faculty of Engineering, University of Western Ontario, London, Canada
    Author URL: https://ieeexplore.ieee.org/author/37532543600
    ID: 37532543600
    Order: 4
    Author Affiliations:
    • Faculty of Engineering, University of Western Ontario, London, Canada
  • Author Name: Jun Yang
    Affiliation: Faculty of Engineering, University of Western Ontario, London, Canada
    Author URL: https://ieeexplore.ieee.org/author/37538611600
    ID: 37538611600
    Order: 5
    Author Affiliations:
    • Faculty of Engineering, University of Western Ontario, London, Canada

Image Sensor

• sensor_type: CMOS
• resolution: 1600 (H) X 1200 (V)
• dynamic_range: Not specified
• pixel_size: 2.8 µm
• dark_current: Below 1.1 mV level

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• frame_rate: 12 fps
• power_consumption: 125 mW
• noise: Low noise below 1.1 mV level

Applications & Benefits

• cell_imaging: The system is capable of real-time monitoring and data analysis for cell cultivation applications, allowing for tracking cell size and distribution within microfluidic environments.
• benefits: The system is portable, cost-effective, uses low energy LED light, provides high resolution, rapid testing capabilities, and consumes minimal resources.

Supporting Organizations

• supported_by: Xiangtan University, Xiangnan University, University of Western Ontario, Superpix Micro Technology Company

Manuscript Details

• publication_date: 19-21 June 2010

Relevancy Score

• score: 10
• missing_fields:
  • dynamic_range
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • signal_to_noise_ratio
  • sensitivity
  • shutter_speed

Processed JSON Filename

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