Lensfree Microscopy A New Framework For The Imaging Of Viruses Bacteria Cells And Tissue

• doi: 10.1109/IEDM.2015.7409690
• title: Lensfree microscopy: A new framework for the imaging of viruses, bacteria, cells and tissue
• publisher: IEEE
• isbn: 978-1-4673-9893-0
• issn: 2156-017X
• rank: 2869
• access_type: LOCKED
• content_type: Conferences
• abstract: Lensfree imaging is an emerging microscopy technique based on in-line holography as invented by Gabor in 1948. Albeit the existence of the method since decades, the recent development of digital sensors, helped the realization of its full potential. Over the recent years, innovations and improvements in CMOS imaging technology design and fabrication have allowed to decrease the pixel pitch down to ~1μm and the number of pixels has dramatically increased up to 250 million of pixels. As a result, the performance of lensfree microscopy, which features a bare CMOS sensor without any magnification optics, have tremendously increased while keeping the design simple, robust, and at a reasonable low cost. The detection ability improved from 10 μm (cell) in 2009, to 1 μm (bacteria) in 2010, down to 100 nm beads in 2012, paving the way to the detection of viruses in 2013.
• article_number: 7409690
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7409690
• html_url: https://ieeexplore.ieee.org/document/7409690/
• abstract_url: https://ieeexplore.ieee.org/document/7409690/
• publication_title: 2015 IEEE International Electron Devices Meeting (IEDM)
• conference_location: Washington, DC, USA
• conference_dates: 7-9 Dec. 2015
• publication_number: 7402013
• is_number: 7409598
• publication_year: 2015
• publication_date: 7-9 Dec. 2015
• start_page: 13.4.1
• end_page: 13.4.5
• citing_paper_count: 0
• citing_patent_count: 4
• download_count: 229
• insert_date: 20160218
• index_terms:
  • ieee_terms:
    • Microscopy
    • Microorganisms
    • Sensors
    • Image reconstruction
    • Viruses (medical)
  • author_terms:
    • CMOS imaging technology
    • lensfree microscopy
    • bio-imaging
  • dynamic_index_terms:
    • Lens-free Microscopy
    • Pixel Pitch
    • Optical Magnification
    • Field Of View
    • Drug Screening
    • Drug Testing
    • Large Field Of View
    • Wide-field Imaging
    • Digital Slide Scanner
    • Color Filter
    • Fundamental Biology
• isbn_formats:
  • format: USB ISBN, value: 978-1-4673-9893-0, isbnType: New-2005
  • format: Electronic ISBN, value: 978-1-4673-9894-7, isbnType: New-2005
• authors:
  • Author Name: C. P. Allier
    Affiliation: Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
    Author URL: https://ieeexplore.ieee.org/author/37085696975
    ID: 37085696975
    Order: 1
    Author Affiliations:
    • Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
  • Author Name: S. Vinjimore Kesavan
    Affiliation: Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
    Author URL: https://ieeexplore.ieee.org/author/37088706676
    ID: 37088706676
    Order: 2
    Author Affiliations:
    • Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
  • Author Name: Y. Hennequin
    Affiliation: Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
    Author URL: https://ieeexplore.ieee.org/author/37085682844
    ID: 37085682844
    Order: 3
    Author Affiliations:
    • Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
  • Author Name: O. Cioni
    Affiliation: Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
    Author URL: https://ieeexplore.ieee.org/author/37088712217
    ID: 37088712217
    Order: 4
    Author Affiliations:
    • Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
  • Author Name: F. Momey
    Affiliation: Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
    Author URL: https://ieeexplore.ieee.org/author/37085710784
    ID: 37085710784
    Order: 5
    Author Affiliations:
    • Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
  • Author Name: T. Bordy
    Affiliation: Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
    Author URL: https://ieeexplore.ieee.org/author/37946755900
    ID: 37946755900
    Order: 6
    Author Affiliations:
    • Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
  • Author Name: L. Herve
    Affiliation: Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
    Author URL: https://ieeexplore.ieee.org/author/37301461200
    ID: 37301461200
    Order: 7
    Author Affiliations:
    • Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
  • Author Name: J.-G. Coutard
    Affiliation: Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
    Author URL: https://ieeexplore.ieee.org/author/37089146631
    ID: 37089146631
    Order: 8
    Author Affiliations:
    • Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
  • Author Name: S. Morel
    Affiliation: Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
    Author URL: https://ieeexplore.ieee.org/author/37088712786
    ID: 37088712786
    Order: 9
    Author Affiliations:
    • Technologies for Healthcare and Biology division, CEA, LETI, MINATEC Campus, Grenoble, France
  • Author Name: A. Berdeu
    Affiliation: Univ. Grenoble Alpes, Grenoble, France
    Author URL: https://ieeexplore.ieee.org/author/37088710726
    ID: 37088710726
    Order: 10
    Author Affiliations:
    • Univ. Grenoble Alpes, Grenoble, France
  • Author Name: F. Navarro
    Affiliation: Univ. Grenoble Alpes, Grenoble, France
    Author URL: https://ieeexplore.ieee.org/author/37947458000
    ID: 37947458000
    Order: 11
    Author Affiliations:
    • Univ. Grenoble Alpes, Grenoble, France
  • Author Name: J.-M. Dinten
    Affiliation: Univ. Grenoble Alpes, Grenoble, France
    Author URL: https://ieeexplore.ieee.org/author/37294303800
    ID: 37294303800
    Order: 12
    Author Affiliations:
    • Univ. Grenoble Alpes, Grenoble, France

Image Sensor

• sensor_type: CMOS
• resolution: 250 million pixels
• dynamic_range: not specified
• pixel_size: ~1 μm
• dark_current: not specified

Optical Data

• focal_length: not specified
• aperture: not specified
• field_of_view: larger than 20 mm²
• distortion: not specified

Performance Metrics

• frame_rate: less than 10 minutes per frame
• signal_to_noise_ratio: up to 100

Applications & Benefits

• cell_imaging: Lensfree microscopy for cell monitoring, capable of detecting various biological objects down to 100 nm, such as viruses.
• benefits: Simple, robust, low cost, large field of view, real-time imaging.

Supporting Organizations

• supported_by: CEA, LETI, MINATEC Campus, Univ. Grenoble Alpes

Manuscript Details

• publication_date: 7-9 Dec. 2015

Relevancy Score

• score: 9
• missing_fields:
  • dynamic_range
  • shutter_speed
  • power_consumption
  • noise
  • focal_length
  • aperture
  • distortion

Processed JSON Filename

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