Laboncmos A Multimodal Cmos Sensor Platform Towards Personalized Dna Sequencing

• doi: 10.1109/ISCAS.2016.7539035
• title: Lab-on-CMOS: A multi-modal CMOS sensor platform towards personalized DNA sequencing
• publisher: IEEE
• isbn: 978-1-4799-5342-4
• issn: 2379-447X
• rank: 2854
• access_type: LOCKED
• content_type: Conferences
• abstract: Precision medicine requires scalable bioinstrument for a personalized DNA sequencing, which can be label-free, cost-efficient, and high-throughput. This paper mainly presents three kinds of CMOS-based label-free sensors, including: i) a high-sensitivity ion-sensitive field-effect transistor (ISFET) sensor with pH-to-time-to-voltage conversion (pH-TVC); ii) a dual-mode sensor with image and chemical modes for high accuracy; and iii) a THz metamaterial sensor with electrical resonance detection. The developed CMOS multi-modal sensor platform can show a scaled solution for future personalized DNA sequencing.
• article_number: 7539035
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7539035
• html_url: https://ieeexplore.ieee.org/document/7539035/
• abstract_url: https://ieeexplore.ieee.org/document/7539035/
• publication_title: 2016 IEEE International Symposium on Circuits and Systems (ISCAS)
• conference_location: Montreal, QC, Canada
• conference_dates: 22-25 May 2016
• publication_number: 7515073
• is_number: 7527154
• publication_year: 2016
• publication_date: 22-25 May 2016
• start_page: 2266
• end_page: 2269
• citing_paper_count: 2
• citing_patent_count: 0
• download_count: 420
• insert_date: 20160811
• index_terms:
  • ieee_terms:
    • DNA
    • Sequential analysis
    • CMOS integrated circuits
    • Sensors
    • Passivation
    • Probes
    • Metamaterials
  • author_terms:
    • personalized DNA sequencing
    • label-free sensors
    • ISFET
    • metamaterial sensor
    • multi-modal
  • dynamic_index_terms:
    • DNA Sequencing
    • Multimodal Sensor
    • Imaging Modalities
    • Metamaterial
    • Polymerase Chain Reaction
    • Genotyping
    • pH Values
    • Microspheres
    • Microbeads
    • DNA Strand
    • Resonance Frequency
    • pH Changes
    • Single-stranded DNA
    • Detection Of DNA
    • Signal Source
    • Passivation Layer
    • Surface Passivation
    • Solution Changes
    • Target DNA Sequence
    • pH Sensitivity
    • Pixel Array
    • Sensor Operation
    • Electrostatic Discharge
    • Leaky-wave Antenna
    • High-sensitivity Sensor
    • Readout Circuit
    • Output Pixel
• isbn_formats:
  • format: Print on Demand(PoD) ISBN, value: 978-1-4799-5342-4, isbnType: New-2005
  • format: USB ISBN, value: 978-1-4799-5340-0, isbnType: New-2005
  • format: Electronic ISBN, value: 978-1-4799-5341-7, isbnType: New-2005
• authors:
  • Author Name: Yu Jiang
    Affiliation: School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore
    Author URL: https://ieeexplore.ieee.org/author/37085387840
    ID: 37085387840
    Order: 1
    Author Affiliations:
    • School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore
  • Author Name: Xu Liu
    Affiliation: School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore
    Author URL: https://ieeexplore.ieee.org/author/37716432000
    ID: 37716432000
    Order: 2
    Author Affiliations:
    • School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore
  • Author Name: Xiwei Huang
    Affiliation: Ministry of Education Key Lab of RF Circuits and Systems, Hangzhou Dianzi University, China
    Author URL: https://ieeexplore.ieee.org/author/37337298700
    ID: 37337298700
    Order: 3
    Author Affiliations:
    • Ministry of Education Key Lab of RF Circuits and Systems, Hangzhou Dianzi University, China
  • Author Name: Yang Shang
    Affiliation: School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore
    Author URL: https://ieeexplore.ieee.org/author/38239612200
    ID: 38239612200
    Order: 4
    Author Affiliations:
    • School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore
  • Author Name: Mei Yan
    Affiliation: School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore
    Author URL: https://ieeexplore.ieee.org/author/38546762500
    ID: 38546762500
    Order: 5
    Author Affiliations:
    • School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore
  • Author Name: Hao Yu
    Affiliation: School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore
    Author URL: https://ieeexplore.ieee.org/author/37275013000
    ID: 37275013000
    Order: 6
    Author Affiliations:
    • School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore

Image Sensor

• sensor_type: CMOS
• resolution: 512x576
• dynamic_range: Not specified
• pixel_size: Not specified
• dark_current: Not specified

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• frame_rate: 375 fps

Applications & Benefits

• cell_imaging: Used for DNA sequencing and biomedical detection applications.
• benefits: Cost-efficient, scalable solution for personalized DNA sequencing.

Supporting Organizations

• supported_by: NRF-POC fund, NTU iFood fund, National Natural Science Foundation (Grant No. 61501156) from China.

Manuscript Details

• publication_date: 22-25 May 2016

Relevancy Score

• score: 9
• missing_fields:
  • dynamic_range
  • pixel_size
  • dark_current
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • signal_to_noise_ratio
  • sensitivity
  • shutter_speed
  • power_consumption
  • noise

Processed JSON Filename

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