Imic Needleshaped Lowpower Monolithic Active Pixel Sensor For Molecular Neuroimaging On Awake And Freely Moving Rats

• doi: 10.1109/NSSMIC.2016.8069414
• title: IMIC — needle-shaped low-power monolithic active pixel sensor for molecular neuroimaging on awake and freely moving rats
• publisher: IEEE
• isbn: 978-1-5090-1643-3
• issn:
• rank: 2679
• access_type: LOCKED
• content_type: Conferences
• abstract: IMIC is a Monolithic Active Pixel Sensor prototype for the MAPSSIC project dedicated to direct detection of low energy β+ rays in the brain of awake and freely-moving rats using CMOS technology. Former experiments using a β+ Si probe developed within the PIXSIC project validated a methodological proof of concept. However, conducting routinely such measurements would require improvements with respect to the passive pixel sensors employed in PIXSIC. The new IMIC circuit is fabricated in a 180 nm CMOS Image Sensor Technology and features a matrix of 16 × 128 pixels, which are 30 × 50 μm2 large. The sensor has a needle-like aspect ratio (610 μm × 12 000 μm). The chip is produced on a 18 μm high-resistivity epitaxial layer substrate. The foreseen application requires high sensitivity to β-rays while being immune to background γ-rays. Another severe constraint is the limited power dissipation in order to minimize the thermal impact on the brain. IMIC is a fully-programmable digital sensor. The pixel design is based on the front-end architecture of the ALPIDE chip. However modifications have been made to store the information inside fired pixels between two readouts allowing low data throughput. The circuit is controlled through the SPI protocol, which allows for setting all the necessary polarization signals. The results of post-layout simulations show a high signal to noise ratio (>40) and low power dissipation of 115 μW/matrix. Laboratory characterization using β-rays validate these predictions and demonstrated that the slow readout can cope with the expected low activity (≈ 120 hits/matrix/s).
• article_number: 8069414
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8069414
• html_url: https://ieeexplore.ieee.org/document/8069414/
• abstract_url: https://ieeexplore.ieee.org/document/8069414/
• publication_title: 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD)
• conference_location: Strasbourg, France
• conference_dates: 29 Oct.-6 Nov. 2016
• publication_number: 8062961
• is_number: 8069358
• publication_year: 2016
• publication_date: 29 Oct.-6 Nov. 2016
• start_page: 1
• end_page: 4
• citing_paper_count: 0
• citing_patent_count: 0
• download_count: 103
• insert_date: 20171019
• index_terms:
  • ieee_terms:
    • Sensors
    • Probes
    • Rats
    • Active pixel sensors
    • Rodents
    • Image quality
    • Power dissipation
  • author_terms:
    • sensor
    • in-vivo molecular imaging
    • β+
    • MAPS
  • dynamic_index_terms:
    • Neuroimaging
    • Brain Imaging
    • Active Sensors
    • Sensor Pixel
    • Awake Rats
    • Active Pixel Sensor
    • Freely-moving Rats
    • Free-moving Rats
    • Monolithic Sensor
    • Freely Moving
    • Epitaxial Layer
    • Epilayer
    • Low Dissipation
    • Data Rate
    • Data Evaluation
    • Optical Fiber
    • Fiber-optic
    • Integration Time
    • Saturation Limit
    • Dark Count Rate
• isbn_formats:
  • format: Print on Demand(PoD) ISBN, value: 978-1-5090-1643-3, isbnType: New-2005
  • format: Electronic ISBN, value: 978-1-5090-1642-6, isbnType: New-2005
• authors:
  • Author Name: Julian Heymes
    Affiliation: CNRS, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37086247485
    ID: 37086247485
    Order: 1
    Author Affiliations:
    • CNRS, Université de Strasbourg, Strasbourg, France
  • Author Name: Luis Ammour
    Affiliation: IMNC UMR 8165, Université Paris-Saclay, Orsay, France
    Author URL: https://ieeexplore.ieee.org/author/37086260493
    ID: 37086260493
    Order: 2
    Author Affiliations:
    • IMNC UMR 8165, Université Paris-Saclay, Orsay, France
  • Author Name: Matthieu Bautista
    Affiliation: CNRS, Aix Marseille Université, Marseille, France
    Author URL: https://ieeexplore.ieee.org/author/37088745699
    ID: 37088745699
    Order: 3
    Author Affiliations:
    • CNRS, Aix Marseille Université, Marseille, France
  • Author Name: Grégory Bertolone
    Affiliation: CNRS, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37398343400
    ID: 37398343400
    Order: 4
    Author Affiliations:
    • CNRS, Université de Strasbourg, Strasbourg, France
  • Author Name: Andrei Dorokhov
    Affiliation: CNRS, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37268868500
    ID: 37268868500
    Order: 5
    Author Affiliations:
    • CNRS, Université de Strasbourg, Strasbourg, France
  • Author Name: Sylvain Fieux
    Affiliation: LNRC, Univ. Lyon 1, Lyon, France
    Author URL: https://ieeexplore.ieee.org/author/37088729701
    ID: 37088729701
    Order: 6
    Author Affiliations:
    • LNRC, Univ. Lyon 1, Lyon, France
  • Author Name: Fabrice Gensolen
    Affiliation: CNRS, Aix Marseille Université, Marseille, France
    Author URL: https://ieeexplore.ieee.org/author/37564180100
    ID: 37564180100
    Order: 7
    Author Affiliations:
    • CNRS, Aix Marseille Université, Marseille, France
  • Author Name: Matthieu Goffe
    Affiliation: CNRS, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37398000700
    ID: 37398000700
    Order: 8
    Author Affiliations:
    • CNRS, Université de Strasbourg, Strasbourg, France
  • Author Name: Fadoua Guezzi-Messaoud
    Affiliation: CNRS, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37073033200
    ID: 37073033200
    Order: 9
    Author Affiliations:
    • CNRS, Université de Strasbourg, Strasbourg, France
  • Author Name: Christine Hu-guo
    Affiliation: CNRS, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/38271523900
    ID: 38271523900
    Order: 10
    Author Affiliations:
    • CNRS, Université de Strasbourg, Strasbourg, France
  • Author Name: Maciej Kachel
    Affiliation: CNRS, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37690518300
    ID: 37690518300
    Order: 11
    Author Affiliations:
    • CNRS, Université de Strasbourg, Strasbourg, France
  • Author Name: Françoise Lefèbvre
    Affiliation: IMNC UMR 8165, Université Paris-Saclay, Orsay, France
    Author URL: https://ieeexplore.ieee.org/author/37407983600
    ID: 37407983600
    Order: 12
    Author Affiliations:
    • IMNC UMR 8165, Université Paris-Saclay, Orsay, France
  • Author Name: Frédéric Pain
    Affiliation: IMNC UMR 8165, Université Paris-Saclay, Orsay, France
    Author URL: https://ieeexplore.ieee.org/author/37331684800
    ID: 37331684800
    Order: 13
    Author Affiliations:
    • IMNC UMR 8165, Université Paris-Saclay, Orsay, France
  • Author Name: Patrick Pangaud
    Affiliation: CNRS, Aix Marseille Université, Marseille, France
    Author URL: https://ieeexplore.ieee.org/author/37418915000
    ID: 37418915000
    Order: 14
    Author Affiliations:
    • CNRS, Aix Marseille Université, Marseille, France
  • Author Name: Laurent Pinot
    Affiliation: IMNC UMR 8165, Université Paris-Saclay, Orsay, France
    Author URL: https://ieeexplore.ieee.org/author/37331681500
    ID: 37331681500
    Order: 15
    Author Affiliations:
    • IMNC UMR 8165, Université Paris-Saclay, Orsay, France
  • Author Name: Marc Winter
    Affiliation: CNRS, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37277330700
    ID: 37277330700
    Order: 16
    Author Affiliations:
    • CNRS, Université de Strasbourg, Strasbourg, France
  • Author Name: Pascale Gisquet-Verrier
    Affiliation: NeuroPSI, Univ. Paris Sud, Orsay, France
    Author URL: https://ieeexplore.ieee.org/author/37088735958
    ID: 37088735958
    Order: 17
    Author Affiliations:
    • NeuroPSI, Univ. Paris Sud, Orsay, France
  • Author Name: Philippe Lanièce
    Affiliation: IMNC UMR 8165, Université Paris-Saclay, Orsay, France
    Author URL: https://ieeexplore.ieee.org/author/37331682900
    ID: 37331682900
    Order: 18
    Author Affiliations:
    • IMNC UMR 8165, Université Paris-Saclay, Orsay, France
  • Author Name: Christian Morel
    Affiliation: CNRS, Aix Marseille Université, Marseille, France
    Author URL: https://ieeexplore.ieee.org/author/37272332600
    ID: 37272332600
    Order: 19
    Author Affiliations:
    • CNRS, Aix Marseille Université, Marseille, France
  • Author Name: Marc-Antoine Verdier
    Affiliation: IMNC UMR 8165, Université Paris-Saclay, Orsay, France
    Author URL: https://ieeexplore.ieee.org/author/37088728998
    ID: 37088728998
    Order: 20
    Author Affiliations:
    • IMNC UMR 8165, Université Paris-Saclay, Orsay, France
  • Author Name: Luc Zimmer
    Affiliation: LNRC, Univ. Lyon 1, Lyon, France
    Author URL: https://ieeexplore.ieee.org/author/37412242800
    ID: 37412242800
    Order: 21
    Author Affiliations:
    • LNRC, Univ. Lyon 1, Lyon, France
  • Author Name: Jerome Baudot
    Affiliation: CNRS, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37398003500
    ID: 37398003500
    Order: 22
    Author Affiliations:
    • CNRS, Université de Strasbourg, Strasbourg, France

Image Sensor

• sensor_type: CMOS
• resolution: 16x128 pixels
• dynamic_range: greater than 40 dB
• pixel_size: 30x50 µm
• dark_current: ~1.15 hits/matrix/s (for integration times around 50ms)

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• signal_to_noise_ratio: >40 dB
• shutter_speed: Rolling shutter when readout is performed.
• power_consumption: 161 mW total for the sensor, with digital power dissipation ranging from 1 to 3 µW depending on integration time.
• noise: 3 hits/matrix/s for dark count rate.

Applications & Benefits

• cell_imaging: Not specified
• benefits: Allows in-vivo molecular imaging on awake and freely moving rats without major trauma or anesthetic bias.

Supporting Organizations

• supported_by: MAPSSIC project, IMNC, PET center of University Hospital of Zurich, BNL (NY, USA)

Manuscript Details

• publication_date: 29 Oct.-6 Nov. 2016

Relevancy Score

• score: 9
• missing_fields:
  • authors
  • publication_date
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • frame_rate
  • sensitivity

Processed JSON Filename

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