Highthroughput Digital Readout System For Realtime Ion Imaging Using Cmos Isfet Arrays

• doi: 10.1109/ISCAS45731.2020.9181096
• title: High-Throughput Digital Readout System for Real-Time Ion Imaging using CMOS ISFET Arrays
• publisher: IEEE
• isbn: 978-1-7281-3320-1
• issn: 2158-1525
• rank: 2635
• access_type: LOCKED
• content_type: Conferences
• abstract: This paper demonstrates a novel readout platform for ISFET-based ion imagers which is capable of performing high-throughput data acquisition and real-time monitoring on high-speed chemical reactions. The front end employs a 128×128 array of integrated ISFET pH sensors fabricated in unmodified CMOS process. The array operates at a frame rate of up to 3000 fps for detecting hydrogen ion diffusion, generating a maximum data stream of 491.52 Mbps. A digital readout system consisting of a readout module for data buffering, an AXI master controller for accessing on-board DDR3 memory and a PCIe subsystem for transmitting data packets is implemented on an Alinx AX7103 development board to link the chip and the PC. The platform capabilities are demonstrated with a real-time ion imaging experiment, by observing the diffusion of NaOH pills in water within 320 ms, visualized on screen with a latency of 0.15 s. Lastly, different image processing algorithms including Gaussian, Bilateral and Non-local Mean are evaluated for noise reduction and an accelerator for the optimum filter is implemented for real-time ion-imaging.
• article_number: 9181096
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=9181096
• html_url: https://ieeexplore.ieee.org/document/9181096/
• abstract_url: https://ieeexplore.ieee.org/document/9181096/
• publication_title: 2020 IEEE International Symposium on Circuits and Systems (ISCAS)
• conference_location: Seville, Spain
• conference_dates: 12-14 Oct 2020
• publication_number: 9179985
• is_number: 9180369
• publication_year: 2020
• publication_date: 12-14 Oct 2020
• start_page: 1
• end_page: 5
• citing_paper_count: 2
• citing_patent_count: 0
• download_count: 273
• insert_date: 20200928
• index_terms:
  • ieee_terms:
    • Ions
    • Real-time systems
    • Imaging
    • Clocks
    • Field programmable gate arrays
    • Throughput
    • Data acquisition
  • dynamic_index_terms:
    • Digital Technologies
    • Ion Images
    • Readout System
    • Chemical Reactions
    • Frame Rate
    • Ion Diffusion
    • Front End
    • Image Processing Algorithms
    • Throughput
    • High Speed
    • Ionic Interactions
    • Flow Data
    • Data Frame
    • Ethernet
    • High Frame Rate
    • Clock Frequency
    • Clock Cycles
    • Bilateral Filter
    • Total Latency
    • Spatial-temporal Information
    • Distinct Spike
• isbn_formats:
  • format: Print ISBN, value: 978-1-7281-3320-1, isbnType: New-2005
• authors:
  • Author Name: Lei Kuang
    Affiliation: Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Imperial College London, London, UK
    Author URL: https://ieeexplore.ieee.org/author/37088354123
    ID: 37088354123
    Order: 1
    Author Affiliations:
    • Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Imperial College London, London, UK
  • Author Name: Junming Zeng
    Affiliation: Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Imperial College London, London, UK
    Author URL: https://ieeexplore.ieee.org/author/37086500251
    ID: 37086500251
    Order: 2
    Author Affiliations:
    • Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Imperial College London, London, UK
  • Author Name: Pantelis Georgiou
    Affiliation: Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Imperial College London, London, UK
    Author URL: https://ieeexplore.ieee.org/author/37302145800
    ID: 37302145800
    Order: 3
    Author Affiliations:
    • Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Imperial College London, London, UK

Image Sensor

• sensor_type: CMOS
• resolution: 128x128
• dynamic_range: Not specified
• pixel_size: Not specified
• dark_current: Not specified

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• frame_rate: 3000 fps

Applications & Benefits

• cell_imaging: Enabled real-time ion imaging experiments and monitoring in applications such as enzyme kinetics, food safety, and recording of neural activities.
• benefits: High-throughput data acquisition, real-time monitoring capabilities.

Supporting Organizations

• supported_by: Centre for Bio-Inspired Technology, Imperial College London

Manuscript Details

• publication_date: 12-14 Oct 2020

Relevancy Score

• score: 10
• missing_fields:
  • dynamic_range
  • fill factor
  • quantum efficiency
  • dark_current
  • signal-to-noise ratio
  • power consumption
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • sensitivity
  • shutter_speed
  • noise

Processed JSON Filename

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