Highdensity 2Mpitch Ph Image Sensor With Highspeed Operation Up To 1933 Fps

• doi: 10.1109/TBCAS.2019.2895069
• title: High-Density 2-μm-Pitch pH Image Sensor With High-Speed Operation up to 1933 fps
• publisher: IEEE
• isbn:
• issn: 1940-9990
• rank: 2619
• access_type: LOCKED
• content_type: Journals
• abstract: Various biosensing platforms for real-time monitoring and mapping of chemical signals in neural networks have been developed based on CMOS process technology. Despite their achievements, however, there remains a demand for an advanced method that can offer detailed insights into cellular functions with higher spatiotemporal resolution. Here, we present a pH image sensor that employs a high-density array of 256 × 256 pixels and readout circuitry designed for fast operation. The sensor's characteristics, such as the pH sensitivity of 55.1 mV/pH and higher frame speed of 1933 fps, are experimentally demonstrated and compared to those of state-of-the-art pH image sensors. Among them, our sensor presents the smallest pitch of 2 μm with a significantly high operation speed. This sensor can successfully detect a pH change, but also transform the measured data to a two-dimensional image series in real time. The practical spatial resolution of images is investigated by an evaluation method that we first propose in this paper. By this method, we confirm that our sensor can discriminate objects distanced over 4 μm apart, which is twice bigger than the pixel pitch. In order to analyze the degraded resolution and image blur, a capacitive coupling effect at an ion-sensitive membrane is suggested as the main factor and demonstrated by simulation.
• article_number: 8625479
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8625479
• html_url: https://ieeexplore.ieee.org/document/8625479/
• abstract_url: https://ieeexplore.ieee.org/document/8625479/
• publication_title: IEEE Transactions on Biomedical Circuits and Systems
• conference_location:
• conference_dates:
• publication_number: 4156126
• is_number: 8672973
• publication_year: 2019
• publication_date: April 2019
• start_page: 352
• end_page: 363
• citing_paper_count: 29
• citing_patent_count: 0
• download_count: 822
• insert_date: 20190124
• index_terms:
  • ieee_terms:
    • Logic gates
    • Transistors
    • Image sensors
    • Ions
    • Biomembranes
    • Chemicals
  • author_terms:
    • High-density array
    • high frame rate
    • ion sensitive field effect transistor (ISFET)
    • pH image sensor
    • pH monitoring
    • spatial resolution
  • dynamic_index_terms:
    • Image Sensor
    • Camera Sensor
    • Spatial Resolution
    • pH Changes
    • Coupling Effect
    • Capacitive Coupling
    • AC-coupled
    • Electrostatic Coupling
    • pH Sensitivity
    • Biosensing Platform
    • Pixel Pitch
    • Real Time Series
    • Real Time-series
    • Standard Solution
    • Membrane Surface
    • Frame Rate
    • Wako Pure Chemical
    • Analog-to-digital Converter
    • Analog-to-digital
    • Digital-to-analog Converter
    • Printed Circuit Board
    • Threshold Voltage
    • Voltage Values
    • Voltage Difference
    • Voltage Deviation
    • Circuit Design
    • Distance In Space
    • Memory Circuits
    • Pixel Array
    • Modulation Transfer Function
    • Optical Transfer Function
    • Potassium Hydrogen Phthalate
    • Potassium Biphthalate
    • Sensor Surface
    • Gate Oxide
    • Gate-oxide
    • Sensor Output
    • Conversion Time
    • Threshold Voltage Shift
    • Biological Environment
• authors:
  • Author Name: You-Na Lee
    Affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
    Author URL: https://ieeexplore.ieee.org/author/37085666164
    ID: 37085666164
    Order: 1
    Author Affiliations:
    • Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
  • Author Name: Takeshi Araki
    Affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
    Author URL: https://ieeexplore.ieee.org/author/37086803855
    ID: 37086803855
    Order: 2
    Author Affiliations:
    • Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
  • Author Name: Yasuyuki Kimura
    Affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
    Author URL: https://ieeexplore.ieee.org/author/37086023263
    ID: 37086023263
    Order: 3
    Author Affiliations:
    • Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
  • Author Name: Fumihiro Dasai
    Affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
    Author URL: https://ieeexplore.ieee.org/author/37858265500
    ID: 37858265500
    Order: 4
    Author Affiliations:
    • Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
  • Author Name: Tatsuya Iwata
    Affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
    Author URL: https://ieeexplore.ieee.org/author/37085650951
    ID: 37085650951
    Order: 5
    Author Affiliations:
    • Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
  • Author Name: Kazuhiro Takahashi
    Affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
    Author URL: https://ieeexplore.ieee.org/author/37290987200
    ID: 37290987200
    Order: 6
    Author Affiliations:
    • Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
  • Author Name: Kazuaki Sawada
    Affiliation: Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan
    Author URL: https://ieeexplore.ieee.org/author/37277567600
    ID: 37277567600
    Order: 7
    Author Affiliations:
    • Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Japan

Image Sensor

• sensor_type: CMOS
• resolution: 256x256
• dynamic_range: 0 V to 1.4 V
• pixel_size: 2 µm x 2 µm
• dark_current: not explicitly stated in the document

Optical Data

• focal_length: not explicitly stated in the document
• aperture: not explicitly stated in the document
• field_of_view: not explicitly stated in the document
• distortion: not explicitly stated in the document

Performance Metrics

• frame_rate: 1933 fps
• signal_to_noise_ratio: not explicitly stated in the document
• sensitivity: 55.1 mV/pH
• shutter_speed: not explicitly stated in the document
• power_consumption: not explicitly stated in the document
• noise: σ = 0.0029 V

Applications & Benefits

• cell_imaging: Real-time imaging of pH changes in biological environments, monitoring chemical signals in neural networks.
• benefits: High spatial resolution, fast operation, capability to visualize measured information in real-time.

Supporting Organizations

• supported_by: JST CREST, Adaptable and Seamless Technology Transfer Program from Japan Science and Technology Agency

Manuscript Details

• publication_date: April 2019

Relevancy Score

• score: 10
• missing_fields:
  • fill factor
  • quantum efficiency
  • readout speed
  • temporal noise
  • fixed-pattern noise
  • analog-to-digital conversion techniques
  • microlenses
  • on-chip colour filters
  • global/rolling shutters
  • backside illumination

Processed JSON Filename

request_3115a1c4-6045-4d24-bf11-ad8e8acfe812-highdensity_2mpitch_ph_image_sensor_with_highspeed_operation_up_to_1933_fps.json