Hemodynamic Imaging Using An Implantable Selfreset Image Sensor

• doi: 10.1109/BioCAS.2016.7833829
• title: Hemodynamic imaging using an implantable self-reset image sensor
• publisher: IEEE
• isbn: 978-1-5090-2960-0
• issn:
• rank: 2576
• access_type: LOCKED
• content_type: Conferences
• abstract: In this study, we examine hemodynamic imaging by using an implantable CMOS image sensor with self-reset pixels. The self-reset function prevents saturation and allows imaging under a high light intensity condition. Thus, effective signal-to-noise ratio (SNR) over the photon shot noise limit in a normal pixel can be achieved. We designed a prototype using a 0.35-pm process. The self-reset function is implemented using a Schmitt trigger inverter driven by a low voltage. A pixel that is relatively small (15 × 15 pm) and consumes low power is applied to an implantable image sensor. An effective SNR of the sensor is approximately 1.5 dB higher than the photon shot noise limit. We demonstrate hemodynamic imaging of a mouse brain by implanting the proposed sensor with a frame synchronized two-color illumination.
• article_number: 7833829
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7833829
• html_url: https://ieeexplore.ieee.org/document/7833829/
• abstract_url: https://ieeexplore.ieee.org/document/7833829/
• publication_title: 2016 IEEE Biomedical Circuits and Systems Conference (BioCAS)
• conference_location: Shanghai, China
• conference_dates: 17-19 Oct. 2016
• publication_number: 7803480
• is_number: 7833706
• publication_year: 2016
• publication_date: 17-19 Oct. 2016
• start_page: 452
• end_page: 455
• citing_paper_count: 2
• citing_patent_count: 0
• download_count: 135
• insert_date: 20170126
• index_terms:
  • ieee_terms:
    • Inverters
    • Image sensors
    • Transistors
    • Hemodynamics
    • Signal to noise ratio
    • Photonics
  • author_terms:
    • Implantable image sensor
    • high effective signal-to-noise ratio
    • self-reset pixel
    • hemodynamic imaging
  • dynamic_index_terms:
    • Image Sensor
    • Camera Sensor
    • Implantable Sensors
    • Hemodynamic Imaging
    • Signal-to-noise
    • Signal-to-noise Ratio
    • Light Intensity
    • Low Voltage
    • Volume Change
    • Changes In Intensity
    • Light Source
    • Square Root
    • High Spatial Resolution
    • Pixel Size
    • Power Consumption
    • Additive Noise
    • Additive White Gaussian Noise
    • Frame Rate
    • Polyethylene Terephthalate
    • Dacron
    • Flexible Substrates
    • Thermal Noise
    • Current Noise
    • Supply Voltage
    • Light Power
    • Fill Factor
    • Incident Light Intensity
    • Voltage-sensitive Dye
    • Potentiometric Dye
    • Reset Voltage
    • Total Noise
• isbn_formats:
  • format: Print on Demand(PoD) ISBN, value: 978-1-5090-2960-0, isbnType: New-2005
  • format: Electronic ISBN, value: 978-1-5090-2959-4, isbnType: New-2005
• authors:
  • Author Name: Kiyotaka Sasagawa
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37287324600
    ID: 37287324600
    Order: 1
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
  • Author Name: Takahiro Yamaguchi
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37085457733
    ID: 37085457733
    Order: 2
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
  • Author Name: Makito Haruta
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/38246962800
    ID: 38246962800
    Order: 3
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
  • Author Name: Yasumi Ohta
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/38548426000
    ID: 38548426000
    Order: 4
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
  • Author Name: Hiroaki Takehara
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37085472943
    ID: 37085472943
    Order: 5
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
  • Author Name: Toshihiko Noda
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37401924800
    ID: 37401924800
    Order: 6
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
  • Author Name: Takashi Tokuda
    Affiliation: Nara Sentan Kagaku Gijutsu Daigakuin Daigaku, Ikoma, Nara, JP
    Author URL: https://ieeexplore.ieee.org/author/37278027500
    ID: 37278027500
    Order: 7
    Author Affiliations:
    • Nara Sentan Kagaku Gijutsu Daigakuin Daigaku, Ikoma, Nara, JP
  • Author Name: Jun Ohta
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278016600
    ID: 37278016600
    Order: 8
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan

Image Sensor

• sensor_type: CMOS
• resolution: 60 x 120 pixels
• dynamic_range: 59 dB
• pixel_size: 15 x 15 µm
• dark_current: not specified

Optical Data

• focal_length: not specified
• aperture: not specified
• field_of_view: not specified
• distortion: not specified

Performance Metrics

• frame_rate: 64 fps (effective for sensor frames; 16 fps for each wavelength)
• signal_to_noise_ratio: approximately 1.5 dB higher than photon shot noise limit
• power_consumption: 0.11 µW
• noise: specific values not provided for noise level but indicated increases with light intensity

Applications & Benefits

• cell_imaging: used for hemodynamic imaging of mouse brain
• benefits: high effective signal-to-noise ratio, capability to detect blood flow and changes in hemoglobin ratio (HbO/HbR)

Supporting Organizations

• supported_by: JSPS KAKENHI Grant Number 26249051 and 15K01289

Manuscript Details

• publication_date: 17-19 Oct. 2016

Relevancy Score

• score: 9
• missing_fields:
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • sensitivity
  • shutter_speed

Processed JSON Filename

request_6723f925-a38f-4f1e-b678-49c0924683c5-hemodynamic_imaging_using_an_implantable_selfreset_image_sensor.json