Digital Autoradiography Using Ccd And Cmos Imaging Technology

• doi: 10.1109/NSSMIC.2006.354442
• title: Digital autoradiography using CCD and CMOS imaging technology
• publisher: IEEE
• isbn: 1-4244-0561-0
• issn: 1082-3654
• partnum: 06CH37832
• rank: 2291
• access_type: LOCKED
• content_type: Conferences
• abstract: CCD and CMOS imaging technologies can be applied to thin tissue autoradiography as potential imaging alternatives to using conventional film. In this work, we compare two particular devices; a CCD operating in slow scan mode and a CMOS-based active pixel sensor, operating at near video rates. Both imaging sensors have been operated at room temperature with images produced from calibrated microscales and radio-labelled tissue samples. We also compare these digital imaging technologies with the use of conventional film. We show first comparative results obtained with 14C calibrated microscales and 35S radiolabelled tissue sections. We also present first results of 3H images produced under direct irradiation of a CCD sensor operating at room temperature. Compared to film, silicon-based imaging technologies exhibit enhanced sensitivity, dynamic range and linearity.
• article_number: 4179556
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4179556
• html_url: https://ieeexplore.ieee.org/document/4179556/
• abstract_url: https://ieeexplore.ieee.org/document/4179556/
• publication_title: 2006 IEEE Nuclear Science Symposium Conference Record
• conference_location: San Diego, CA, USA
• conference_dates: 29 Oct.-1 Nov. 2006
• publication_number: 4143535
• is_number: 4179395
• publication_year: 2006
• publication_date: 29 Oct.-1 Nov. 2006
• start_page: 2607
• end_page: 2612
• citing_paper_count: 1
• citing_patent_count: 0
• download_count: 173
• insert_date: 20070507
• index_terms:
  • ieee_terms:
    • CMOS technology
    • Charge coupled devices
    • Temperature sensors
    • CMOS image sensors
    • Image sensors
    • Digital images
    • Charge-coupled image sensors
    • Semiconductor films
    • Dynamic range
    • Linearity
  • author_terms:
    • Digital Autoradiography
    • CCD
    • CMOS
    • APS
    • tissue imaging
    • high resolution
  • dynamic_index_terms:
    • CCD Camera
    • Charge-coupled Device
    • Digital Autoradiography
    • CCD Technology
    • Tissue Sections
    • Dynamic Range
    • Image Sensor
    • Camera Sensor
    • Active Sensors
    • Direct Radiation
    • Direct Irradiation
    • Video Rate
    • Video Evaluation
    • Conventional Film
    • Exposure Time
    • Low Sensitivity
    • Effect Of Density
    • Linear Response
    • Energy Spectrum
    • Image Quantification
    • Passivation Layer
    • Surface Passivation
    • Composite Image
    • Mean Energy
    • Noise Floor
    • Background Events
    • ROI Analysis
    • Solid-state Detector
    • Solid-state Nuclear Track Detectors
    • Mean Pixel
    • Pixel Array
    • Epitaxial Layer
    • Epilayer
    • Multiwire
    • Multiwire Proportional Chambers
    • MWPC
• isbn_formats:
  • format: CD, value: 1-4244-0561-0, isbnType: Historical
  • format: Print ISBN, value: 1-4244-0560-2, isbnType: Historical
• authors:
  • Author Name: J. Cabello
    Affiliation: Centre for Vision, Speech and Signal Processing, School of Electronics and Physical Sciences, University of Surrey, Guildford, UK
    Author URL: https://ieeexplore.ieee.org/author/37289893000
    ID: 37289893000
    Order: 1
    Author Affiliations:
    • Centre for Vision, Speech and Signal Processing, School of Electronics and Physical Sciences, University of Surrey, Guildford, UK
  • Author Name: A. Bailey
    Affiliation: School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    Author URL: https://ieeexplore.ieee.org/author/37301785600
    ID: 37301785600
    Order: 2
    Author Affiliations:
    • School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
  • Author Name: I. Kitchen
    Affiliation: School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    Author URL: https://ieeexplore.ieee.org/author/37295950900
    ID: 37295950900
    Order: 3
    Author Affiliations:
    • School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
  • Author Name: A. Clark
    Affiliation: Rutherford Appleton Laboratory, CCLRC, Chilton, UK
    Author URL: https://ieeexplore.ieee.org/author/37290996500
    ID: 37290996500
    Order: 4
    Author Affiliations:
    • Rutherford Appleton Laboratory, CCLRC, Chilton, UK
  • Author Name: J. Crooks
    Affiliation: Rutherford Appleton Laboratory, CCLRC, Chilton, UK
    Author URL: https://ieeexplore.ieee.org/author/37295406000
    ID: 37295406000
    Order: 5
    Author Affiliations:
    • Rutherford Appleton Laboratory, CCLRC, Chilton, UK
  • Author Name: R. Halsall
    Affiliation: Rutherford Appleton Laboratory, CCLRC, Chilton, UK
    Author URL: https://ieeexplore.ieee.org/author/37295406900
    ID: 37295406900
    Order: 6
    Author Affiliations:
    • Rutherford Appleton Laboratory, CCLRC, Chilton, UK
  • Author Name: M. Key-Charriere
    Affiliation: Rutherford Appleton Laboratory, CCLRC, Chilton, UK
    Author URL: https://ieeexplore.ieee.org/author/38308480600
    ID: 38308480600
    Order: 7
    Author Affiliations:
    • Rutherford Appleton Laboratory, CCLRC, Chilton, UK
  • Author Name: S. Martin
    Affiliation: Rutherford Appleton Laboratory, CCLRC, Chilton, UK
    Author URL: https://ieeexplore.ieee.org/author/38366722000
    ID: 38366722000
    Order: 8
    Author Affiliations:
    • Rutherford Appleton Laboratory, CCLRC, Chilton, UK
  • Author Name: M. Prydderch
    Affiliation: Rutherford Appleton Laboratory, CCLRC, Chilton, UK
    Author URL: https://ieeexplore.ieee.org/author/37295411100
    ID: 37295411100
    Order: 9
    Author Affiliations:
    • Rutherford Appleton Laboratory, CCLRC, Chilton, UK
  • Author Name: R. Turchetta
    Affiliation: Rutherford Appleton Laboratory, CCLRC, Chilton, UK
    Author URL: https://ieeexplore.ieee.org/author/37295412200
    ID: 37295412200
    Order: 10
    Author Affiliations:
    • Rutherford Appleton Laboratory, CCLRC, Chilton, UK
  • Author Name: K. Wells
    Affiliation: Centre for Vision, Speech and Signal Processing, School of Electronics and Physical Sciences, University of Surrey, Guildford, UK
    Author URL: https://ieeexplore.ieee.org/author/37295366500
    ID: 37295366500
    Order: 11
    Author Affiliations:
    • Centre for Vision, Speech and Signal Processing, School of Electronics and Physical Sciences, University of Surrey, Guildford, UK

Image Sensor

• sensor_type: CMOS
• resolution: 525 x 525
• dynamic_range: unknown
• pixel_size: 2.5 μm
• dark_current: unknown

Optical Data

• focal_length: unknown
• aperture: unknown
• field_of_view: unknown
• distortion: unknown

Performance Metrics

• frame_rate: 10 frames s−1
• signal_to_noise_ratio: unknown
• sensitivity: 175 counts/kBq/g (CMS sensor)
• shutter_speed: unknown
• power_consumption: unknown
• noise: 18 fF

Applications & Benefits

• cell_imaging: CMOS sensor used for autoradiography imaging in biomedical applications.
• benefits: Lower cost alternative, lower power consumption, high level of integration, radiation hardness, and high-speed operation.

Supporting Organizations

• supported_by: Natural Environment Research Council (NERC), Engineering and Physical Sciences Research Council (EPSRC), University of Surrey.

Manuscript Details

• publication_date: 29 Oct.-1 Nov. 2006

Relevancy Score

• score: 10
• missing_fields:
  • dynamic_range
  • dark_current
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • signal_to_noise_ratio
  • shutter_speed
  • power_consumption

Processed JSON Filename

request_7535d6d7-a7d5-4399-8e13-b48e18d2df82-digital_autoradiography_using_ccd_and_cmos_imaging_technology.json