Development Of A Cmos Imaging Device For Functional Imaging Inside The Mouse Brain

• doi: 10.1109/APCCAS.2006.342180
• title: Development of a CMOS Imaging Device for Functional Imaging Inside the Mouse Brain
• publisher: IEEE
• isbn: 1-4244-0387-1
• issn:
• partnum: 06EX1378
• rank: 2243
• access_type: LOCKED
• content_type: Conferences
• abstract: We propose the use of a CMOS image sensor for in vivo functional imaging of the mouse brain. A dedicated image sensor with 176 times 144 pixels array is designed, fabricated, and packaged to enable on-chip fluorescence imaging. Using this configuration, we have successfully performed imaging inside the intact mouse brain. Furthermore, we have demonstrated functional imaging inside the mouse brain. This is done in conjunction with a fluorogenic substrate, which detects the presence of serine protease inside the brain. By imaging the fluorescence signal upon injection of a stimulant, we have successfully measured the brain protease activity and accurately determined its reaction onset, which is close to 1 hr 28 min after injection of the stimulant. This method represents a new approach for neural imaging using an inexpensive CMOS imaging device
• article_number: 4145532
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4145532
• html_url: https://ieeexplore.ieee.org/document/4145532/
• abstract_url: https://ieeexplore.ieee.org/document/4145532/
• publication_title: APCCAS 2006 - 2006 IEEE Asia Pacific Conference on Circuits and Systems
• conference_location: Singapore
• conference_dates: 4-7 Dec. 2006
• publication_number: 4145316
• is_number: 4118066
• publication_year: 2006
• publication_date: 4-7 Dec. 2006
• start_page: 872
• end_page: 875
• citing_paper_count: 0
• citing_patent_count: 0
• download_count: 71
• insert_date: 20070410
• index_terms:
  • ieee_terms:
    • Mice
    • Optical imaging
    • CMOS image sensors
    • CMOS technology
    • Positron emission tomography
    • In vivo
    • Image sensors
    • Fluorescence
    • Spatial resolution
    • Magnetic resonance imaging
  • author_terms:
    • CMOS image sensor
    • in vivo
    • functional imaging
    • brain
  • dynamic_index_terms:
    • Functional Imaging
    • Mouse Brain
    • Brains Of Mice
    • Imaging Device
    • Neuroimaging
    • Brain Imaging
    • Serine Protease
    • Image Sensor
    • Camera Sensor
    • Intact Brain
    • Neural Image
    • High-resolution
    • Significantly Increased
    • Illumination
    • Lighting
    • End Of The Experiment
    • Frame Rate
    • Excitation Light
    • Serine Protease Activity
• isbn_formats:
  • format: Print ISBN, value: 1-4244-0387-1, isbnType: Historical
  • format: Print ISBN, value: 1-4244-0386-3, isbnType: Historical
• authors:
  • Author Name: David C. Ng
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278114700
    ID: 37278114700
    Order: 1
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Takashi Tokuda
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278027500
    ID: 37278027500
    Order: 2
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Takuma Nakagawa
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37286387500
    ID: 37286387500
    Order: 3
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Hideki Tamura
    Affiliation: Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37290561300
    ID: 37290561300
    Order: 4
    Author Affiliations:
    • Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Masahiro Nunoshita
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278019400
    ID: 37278019400
    Order: 5
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Yasuyuki Ishikawa
    Affiliation: Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37292335500
    ID: 37292335500
    Order: 6
    Author Affiliations:
    • Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Sadao Shiosaka
    Affiliation: Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37294918400
    ID: 37294918400
    Order: 7
    Author Affiliations:
    • Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Jun Ohta
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278016600
    ID: 37278016600
    Order: 8
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan

Image Sensor

• sensor_type: CMOS
• resolution: 176 × 144 pixels
• dynamic_range: 44 dB (attenuation achieved by filter)
• pixel_size: 7.5 × 7.5 µm²
• dark_current: not specified

Optical Data

• focal_length: not specified
• aperture: not specified
• field_of_view: not specified
• distortion: not specified

Performance Metrics

• frame_rate: 0.08 – 16.5 fps

Applications & Benefits

• cell_imaging: In vivo functional imaging of the mouse brain for studying brain protease activity and neural functions.
• benefits: New approach for neural imaging using inexpensive CMOS imaging device, minimal injury to brain, ability to perform real-time imaging and monitoring.

Supporting Organizations

• supported_by: Semiconductor Technology Academic Research Center (STARC); Ministry of Education, Culture, Sports, Science and Technology under Grants-in-Aid #16650108 and #16360175.

Manuscript Details

• publication_date: 4-7 Dec. 2006

Relevancy Score

• score: 10
• missing_fields:
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • signal_to_noise_ratio
  • sensitivity
  • shutter_speed
  • power_consumption
  • noise

Processed JSON Filename

request_205e4c74-a20a-45dc-8f7f-dd0b86476045-development_of_a_cmos_imaging_device_for_functional_imaging_inside_the_mouse_brain.json