Design Of An Integrated Sensor For Noninvasive Optical Mammography Based On Frequencydomain Nir Spectroscopy

• doi: 10.1109/BIOCAS.2008.4696905
• title: Design of an integrated sensor for noninvasive optical mammography based on frequency-domain NIR spectroscopy
• publisher: IEEE
• isbn: 978-1-4244-2879-3
• issn: 2163-4025
• partnum: 08EX2555
• rank: 2191
• access_type: LOCKED
• content_type: Conferences
• abstract: Time-resolved techniques for optical spectroscopy are emerging as a promising diagnostic tool for mammography providing richer information content of optical images and improved tumor detectability. This paper presents the design of an integrated optical sensor for phase and amplitude detection of RF-modulated optical signals up to 110 MHz in the near-infrared (NIR) region (650-850 nm) for use in frequency-domain instruments that measure both amplitude and phase changes in photon migration between source and detector. The sensor consists of an NIR-sensitive photodetector monolithically integrated with front-end analog amplifier and signal processing circuitry for amplitude and phase detection in an unmodified CMOS process. The differential transimpedance amplifier (TIA) achieves a transimpedance-bandwidth product of 28 THzOmega and input-referred current noise of 1.92 pA/radicHz at 110 MHz. The amplitude detector exhibits 49.2 mV/muA resolution with 0.5% linearity and 26 dB dynamic range. The proposed phase detector can detect 360 degree phase difference with phase resolution of 5 mV/degree. The sensor is implemented in a 0.18 mum CMOS technology and consumes 22.5 mW from a 1.8 V supply voltage. The integrated sensor presented is envisaged as a building block towards a low-power, low-cost optical sensor array system for concurrent measurement of multiple tissue sites, thus improving spatial resolution.
• article_number: 4696905
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4696905
• html_url: https://ieeexplore.ieee.org/document/4696905/
• abstract_url: https://ieeexplore.ieee.org/document/4696905/
• publication_title: 2008 IEEE Biomedical Circuits and Systems Conference
• conference_location: Baltimore, MD, USA
• conference_dates: 20-22 Nov. 2008
• publication_number: 4693717
• is_number: 4696849
• publication_year: 2008
• publication_date: 20-22 Nov. 2008
• start_page: 185
• end_page: 188
• citing_paper_count: 2
• citing_patent_count: 0
• download_count: 305
• insert_date: 20090220
• index_terms:
  • ieee_terms:
    • Optical sensors
    • Optical design
    • Integrated optics
    • Mammography
    • Spectroscopy
    • Optical signal processing
    • Phase detection
    • Sensor arrays
    • Phase frequency detector
    • Optical amplifiers
  • dynamic_index_terms:
    • Near-infrared Spectroscopy
    • Near-infrared Spectra
    • Frequency Domain Spectroscopy
    • Dynamic Range
    • Phase Difference
    • Photodetector
    • Optical Sensors
    • Near-infrared Region
    • Phase Detection
    • Phase Demodulation
    • Transimpedance Amplifier
    • Input-referred Noise
    • Phase Resolution
    • Frequency Domain
    • Signal Amplitude
    • Current Source
    • Current Regulations
    • Quantum Efficiency
    • Phase Delay
    • Parasitic Capacitance
    • Large Dynamic Range
    • Increase In Noise
    • Avalanche Photodiode
    • Feedback Resistor
    • Rising Edge
    • Input Amplitude
    • Input Signal Amplitude
• isbn_formats:
  • format: CD, value: 978-1-4244-2879-3, isbnType: New-2005
  • format: Print ISBN, value: 978-1-4244-2878-6, isbnType: New-2005
• authors:
  • Author Name: Ruida Yun
    Affiliation: Department of Electrical & Computer Engineering, Tufts University, Medford, MA, USA
    Author URL: https://ieeexplore.ieee.org/author/37408673700
    ID: 37408673700
    Order: 1
    Author Affiliations:
    • Department of Electrical & Computer Engineering, Tufts University, Medford, MA, USA
  • Author Name: Valencia M. Joyner
    Affiliation: Department of Electrical & Computer Engineering, Tufts University, Medford, MA, USA
    Author URL: https://ieeexplore.ieee.org/author/37398806400
    ID: 37398806400
    Order: 2
    Author Affiliations:
    • Department of Electrical & Computer Engineering, Tufts University, Medford, MA, USA

Image Sensor

• sensor_type: CMOS
• resolution: Not specified
• dynamic_range: 26dB
• pixel_size: 60x60 μm2
• dark_current: Not specified

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• power_consumption: 22.5 mW
• noise: 1.92 pA/√Hz @ 110MHz

Applications & Benefits

• cell_imaging: Not specified
• benefits: Non-invasive, free of ionizing radiation, portable, economical compared to PET or MRI.

Supporting Organizations

• supported_by: Prof. Fantini and Prof. Sonkusale

Manuscript Details

• publication_date: 20-22 Nov. 2008

Relevancy Score

• score: 8
• missing_fields:
  • resolution
  • pixel_size
  • dark_current
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • frame_rate
  • signal_to_noise_ratio
  • sensitivity
  • shutter_speed

Processed JSON Filename

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