Cmos Contact Imager For Monitoring Cultured Cells

• doi: 10.1109/ISCAS.2005.1465381
• title: CMOS contact imager for monitoring cultured cells
• publisher: IEEE
• isbn: 0-7803-8834-8
• issn: 2158-1525
• partnum: 05CH37618
• rank: 1810
• access_type: LOCKED
• content_type: Conferences
• abstract: There is a growing interest in developing low cost, low power, highly integrated biosensor systems to characterize individual cells for applications such as cell analysis, drug development, environmental monitoring, and medicine. In such micro-systems, it is desirable to track individual cells in real time in order to steer cells using on-chip micro-actuators or monitor the movement of motile cells. To address this requirement, we are developing an embedded optical image sensor, called a contact imager, for imaging of a biological specimen directly coupled to the chip surface. The designed CMOS image sensor comprises an array of active pixel sensors (APS), logic and control signal generation, and readout circuits. The pixel layout has a pitch of 8.4 /spl mu/m (24 /spl lambda/). The design was fabricated in a commercially available 0.5 /spl mu/m CMOS technology. The imager was first characterized on the bench as a normal CMOS image sensor, and then as a contact imager with microbeads (16 /spl mu/m) placed directly on the chip surface. After further packaging with bio-compatible material, the chip was tested with cells cultured directly on the chip surface. Test results confirm successful detection of both beads and cells.
• article_number: 1465381
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=1465381
• html_url: https://ieeexplore.ieee.org/document/1465381/
• abstract_url: https://ieeexplore.ieee.org/document/1465381/
• publication_title: 2005 IEEE International Symposium on Circuits and Systems (ISCAS)
• conference_location: Kobe, Japan
• conference_dates: 23-26 May 2005
• publication_number: 9898
• is_number: 31469
• publication_year: 2005
• publication_date: 23-26 May 2005
• start_page: 3491
• end_page: 3494 Vol. 4
• citing_paper_count: 6
• citing_patent_count: 22
• download_count: 279
• insert_date: 20050725
• index_terms:
  • ieee_terms:
    • Monitoring
    • Cells (biology)
    • CMOS image sensors
    • Sensor arrays
    • Biosensors
    • Logic arrays
    • CMOS logic circuits
    • CMOS technology
    • Costs
    • Drugs
  • dynamic_index_terms:
    • Individual Cells
    • Cell Motility
    • Cell Movement
    • Microspheres
    • Microbeads
    • Signal Propagation
    • Signal Generator
    • Image Sensor
    • Camera Sensor
    • Biocompatible Materials
    • Biomedical Materials
    • Sensor Array
    • Chip Surface
    • Real-time Cell
    • Sensor Pixel
    • Readout Circuit
    • Cell Monolayers
    • Phase Shift
    • Photodiode
    • Pixel Array
    • Clock Signal
    • Test Fixture
    • Neutral Red Dye
    • Image Chips
    • Test Board
    • Small Pixel Size
• isbn_formats:
  • format: Print ISBN, value: 0-7803-8834-8, isbnType: Historical
• authors:
  • Author Name: Honghao Ji
    Affiliation: Department of Electrical and Computer Engineering, Institute for Systems Research, University of Maryland, College Park, MD, USA
    Author URL: https://ieeexplore.ieee.org/author/37087217772
    ID: 37087217772
    Order: 1
    Author Affiliations:
    • Department of Electrical and Computer Engineering, Institute for Systems Research, University of Maryland, College Park, MD, USA
  • Author Name: P.A. Abshire
    Affiliation: Department of Electrical and Computer Engineering, Institute for Systems Research, University of Maryland, College Park, MD, USA
    Author URL: https://ieeexplore.ieee.org/author/37270824500
    ID: 37270824500
    Order: 2
    Author Affiliations:
    • Department of Electrical and Computer Engineering, Institute for Systems Research, University of Maryland, College Park, MD, USA
  • Author Name: M. Urdaneta
    Affiliation: Department of Electrical and Computer Engineering, Institute for Systems Research, University of Maryland, College Park, MD, USA
    Author URL: https://ieeexplore.ieee.org/author/37424249400
    ID: 37424249400
    Order: 3
    Author Affiliations:
    • Department of Electrical and Computer Engineering, Institute for Systems Research, University of Maryland, College Park, MD, USA
  • Author Name: E. Smela
    Affiliation: Department of Electrical and Computer Engineering, Institute for Systems Research, University of Maryland, College Park, MD, USA
    Author URL: https://ieeexplore.ieee.org/author/37270797200
    ID: 37270797200
    Order: 4
    Author Affiliations:
    • Department of Electrical and Computer Engineering, Institute for Systems Research, University of Maryland, College Park, MD, USA

Image Sensor

• sensor_type: CMOS
• resolution: 96x96
• dynamic_range: 53.6dB
• pixel_size: 8.4 µm
• dark_current: 0.46 V/sec

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• noise: σ=2.5 mV over 2 ms

Applications & Benefits

• cell_imaging: The contact imager is able to detect individual cells in real time and monitor their movements.
• benefits: Low-cost, low-power imaging for integrated biosystems.

Supporting Organizations

• supported_by: National Science Foundation (NSF), Laboratory for Physical Sciences (LPS), MOSIS

Manuscript Details

• publication_date: 23-26 May 2005

Relevancy Score

• score: 9
• missing_fields:
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • frame_rate
  • signal_to_noise_ratio
  • sensitivity
  • shutter_speed
  • power_consumption

Processed JSON Filename

request_cd843148-2bf2-45aa-a19b-ed831cdb097a-cmos_contact_imager_for_monitoring_cultured_cells.json