An In Vitro Demonstration Of Cmosbased Optoelectronic Neural Interface Device For Optogenetics

• doi: 10.1109/EMBC.2013.6609621
• title: An in vitro demonstration of CMOS-based optoelectronic neural interface device for optogenetics
• publisher: IEEE
• isbn: 978-1-4577-0216-7
• issn: 1558-4615
• rank: 1584
• access_type: LOCKED
• content_type: Conferences
• abstract: A CMOS-based neural interface device equipped with an integrated micro light source array for optogenetics was fabricated and demonstrated. A GaInN LED array formed on sapphire substrate was successfully assembled with a multifunctional CMOS image sensor that is capable of on-chip current injection. We demonstrated a functionality of light stimulation onto ChR2-expressed cells in an in vitro experiment. A ChR2-expressed cell were successfully stimulated with the light emitted from the fabricated device.
• article_number: 6609621
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6609621
• html_url: https://ieeexplore.ieee.org/document/6609621/
• abstract_url: https://ieeexplore.ieee.org/document/6609621/
• publication_title: 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
• conference_location: Osaka, Japan
• conference_dates: 3-7 July 2013
• publication_number: 6596169
• is_number: 6609410
• publication_year: 2013
• publication_date: 3-7 July 2013
• start_page: 799
• end_page: 802
• citing_paper_count: 3
• citing_patent_count: 0
• download_count: 220
• insert_date: 20130926
• index_terms:
  • ieee_terms:
    • Light emitting diodes
    • Arrays
    • CMOS image sensors
    • System-on-chip
    • In vitro
    • Performance evaluation
    • CMOS integrated circuits
  • dynamic_index_terms:
    • Optogenetic
    • Optoelectronic Devices
    • Neural Devices
    • Current Injection
    • Light Stimulation
    • Sapphire Substrate
    • Light-emitting Diode Array
    • Multifunctional Sensor
    • Emission Intensity
    • Emission Factors
    • Device Performance
    • Sensor Chip
    • N2a Cells
    • Neuro-2a Cells
    • Semiconductor Industry
    • Semiconductor Manufacturing
    • Semiconductor Fabrication
    • Device Architecture
• isbn_formats:
  • format: Electronic ISBN, value: 978-1-4577-0216-7, isbnType: New-2005
• authors:
  • Author Name: T. Tokuda
    Affiliation: Nara Sentan Kagaku Gijutsu Daigakuin Daigaku, Ikoma, Nara, JP
    Author URL: https://ieeexplore.ieee.org/author/37278027500
    ID: 37278027500
    Order: 1
    Author Affiliations:
    • Nara Sentan Kagaku Gijutsu Daigakuin Daigaku, Ikoma, Nara, JP
  • Author Name: S. Nakajima
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37074928400
    ID: 37074928400
    Order: 2
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Y Maezawa
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/38232422200
    ID: 38232422200
    Order: 3
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: T. Noda
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37401924800
    ID: 37401924800
    Order: 4
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: K. Sasagawa
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37287324600
    ID: 37287324600
    Order: 5
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Y. Ishikawa
    Affiliation: Graduate School of Bioscience, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37279796900
    ID: 37279796900
    Order: 6
    Author Affiliations:
    • Graduate School of Bioscience, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: S. Shiosaka
    Affiliation: Graduate School of Bioscience, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37294918400
    ID: 37294918400
    Order: 7
    Author Affiliations:
    • Graduate School of Bioscience, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: J. Ohta
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278016600
    ID: 37278016600
    Order: 8
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan

Image Sensor

• sensor_type: CMOS
• resolution: 260x244
• dynamic_range: not specified
• pixel_size: 7.5µm x 7.5µm
• dark_current: not specified

Optical Data

• focal_length: not specified
• aperture: not specified
• field_of_view: not specified
• distortion: not specified

Performance Metrics

Applications & Benefits

• cell_imaging: The device is used for cell imaging applications, particularly in optogenetics and neural stimulation.
• benefits: The CMOS-based device allows for multi-site patterned stimulation and provides enhanced functionality with integrated light sources.

Supporting Organizations

• supported_by: Japan Science and Technology Agency, VLSI Design and Education Center, University of Tokyo, Cadence Design Systems, Inc.

Manuscript Details

• publication_date: 3-7 July 2013

Relevancy Score

• score: 8
• missing_fields:
  • fill factor
  • quantum efficiency
  • readout speed
  • noise sources
  • analog-to-digital conversion techniques
  • microlenses
  • on-chip colour filters
  • global or rolling shutters
  • backside illumination

Processed JSON Filename

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