An Alldigital Timegated 128X128 Spad Array For Onchip Filterless Fluorescence Detection

• doi: 10.1109/TRANSDUCERS.2011.5969324
• title: An all-digital, time-gated 128X128 spad array for on-chip, filter-less fluorescence detection
• publisher: IEEE
• isbn: 978-1-4577-0155-9
• issn: 2159-547X
• partnum: 11TH9206
• rank: 1540
• access_type: LOCKED
• content_type: Conferences
• abstract: This paper presents an on-chip, filter-less fluorescence detector using an all-digital, time-resolved imager based on a CMOS single-photon detector array with limited in situ processing. The device comprises an array of pixels capable of detecting single photons integrated with time gating circuitry and a 1-bit memory. The sensor allows on-chip, filter-less fluorescence detection and fluorescence lifetime imaging microscopy (FLIM) for micro total analysis systems (μ-TAS) and point-of-care testing (POCT) applications. The sensor was tested as an on-chip optical DNA detector using Cy5 labeled DNA molecules directly placed on the sensor surface.
• article_number: 5969324
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=5969324
• html_url: https://ieeexplore.ieee.org/document/5969324/
• abstract_url: https://ieeexplore.ieee.org/document/5969324/
• publication_title: 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference
• conference_location: Beijing, China
• conference_dates: 5-9 June 2011
• publication_number: 5958191
• is_number: 5969118
• publication_year: 2011
• publication_date: 5-9 June 2011
• start_page: 1180
• end_page: 1183
• citing_paper_count: 18
• citing_patent_count: 1
• download_count: 1056
• insert_date: 20110801
• index_terms:
  • ieee_terms:
    • Fluorescence
    • Pixel
    • Optical filters
    • DNA
    • System-on-a-chip
    • Photonics
    • Arrays
  • author_terms:
    • CMOS
    • SPAD
    • TCSPC
    • Fluorescence detection
  • dynamic_index_terms:
    • Fluorescence Detection
    • Single-photon Avalanche Diode
    • Single-photon Avalanche Diode Array
    • Point-of-care Testing
    • Sensor Surface
    • Fluorescence Lifetime Imaging Microscopy
    • FLIM
    • Fluorescence Lifetime Imaging
    • Laser Pulse
    • Polydimethylsiloxane
    • Time-correlated Single-photon Counting
    • TCSPC
    • Dark Count Rate
• isbn_formats:
  • format: CD, value: 978-1-4577-0155-9, isbnType: New-2005
  • format: Print ISBN, value: 978-1-4577-0157-3, isbnType: New-2005
  • format: Electronic ISBN, value: 978-1-4577-0156-6, isbnType: New-2005
• authors:
  • Author Name: Y. Maruyama
    Affiliation: Circuits and Systems, Delft University of Technnology, Delft, Netherlands
    Author URL: https://ieeexplore.ieee.org/author/37672443200
    ID: 37672443200
    Order: 1
    Author Affiliations:
    • Circuits and Systems, Delft University of Technnology, Delft, Netherlands
  • Author Name: E. Charbon
    Affiliation: Circuits and Systems, Delft University of Technnology, Delft, Netherlands
    Author URL: https://ieeexplore.ieee.org/author/37271353200
    ID: 37271353200
    Order: 2
    Author Affiliations:
    • Circuits and Systems, Delft University of Technnology, Delft, Netherlands

Image Sensor

• sensor_type: CMOS
• resolution: 128 x 128 pixels
• dynamic_range: not specified
• pixel_size: 25 μm
• dark_current: median DCR: 78 Hz at Ve=3V

Optical Data

• focal_length: not specified
• aperture: not specified
• field_of_view: not specified
• distortion: not specified

Performance Metrics

• frame_rate: 2441 fps
• power_consumption: 363 mW
• noise: 3.5 % PRNU

Applications & Benefits

• cell_imaging: On-chip optical DNA detection and fluorescence imaging.
• benefits: Filter-less fluorescence detection, suitable for μ-TAS and POCT systems.

Supporting Organizations

• supported_by: École polytechnique fédérale de Lausanne, Delft University of Technology

Manuscript Details

• publication_date: 5-9 June 2011

Relevancy Score

• score: 10
• missing_fields:
  • dynamic_range
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • signal_to_noise_ratio
  • sensitivity
  • shutter_speed

Processed JSON Filename

request_048c24b8-e047-4b08-85b4-23edd710e9d5-an_alldigital_timegated_128x128_spad_array_for_onchip_filterless_fluorescence_detection.json