A Wireless Multicolor Fluorescence Image Sensor Implant For Realtime Monitoring In Cancer Therapy

• doi: 10.1109/JSSC.2024.3435736
• title: A Wireless, Multicolor Fluorescence Image Sensor Implant for Real-Time Monitoring in Cancer Therapy
• publisher: IEEE
• isbn:
• issn: 1558-173X
• rank: 998
• access_type: LOCKED
• content_type: Journals
• abstract: Real-time monitoring of dynamic biological processes in the body is critical to understanding disease progression and treatment response. These data, for instance, can help address the lower than 50% response rates to cancer immunotherapy. However, current clinical imaging modalities lack the molecular contrast, resolution, and chronic usability for rapid and accurate response assessments. Here, we present a fully wireless image sensor featuring a $2.5{\times }5$ mm2 CMOS integrated circuit for multicolor fluorescence imaging deep in tissue. The sensor operates wirelessly via ultrasound (US) at 5-cm depth in oil, harvesting energy with 221-mW/cm2 incident US power density (31% of FDA limits) and backscattering data at 13 kb/s with a bit error rate $\lt 10{^{-6}}$ . In situ fluorescence excitation is provided by micro-laser diodes controlled with a programmable on-chip driver. An optical front-end combining a multi-bandpass interference filter and a fiber optic plate (FOP) provides >6 OD excitation blocking and enables three-color imaging for detecting multiple cell types. A $36{\times }40$ pixel array captures images with <125- $\mu $ m resolution. We demonstrate wireless, dual-color fluorescence imaging of both effector and suppressor immune cells in ex vivo mouse tumor samples with and without immunotherapy. These results show promise for providing rapid insight into therapeutic response and resistance, guiding personalized medicine.
• article_number: 10630875
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10630875
• html_url: https://ieeexplore.ieee.org/document/10630875/
• abstract_url: https://ieeexplore.ieee.org/document/10630875/
• publication_title: IEEE Journal of Solid-State Circuits
• conference_location:
• conference_dates:
• publication_number: 4
• is_number: 10736122
• publication_year: 2024
• publication_date: Nov. 2024
• start_page: 3580
• end_page: 3598
• citing_paper_count: 1
• citing_patent_count: 0
• download_count: 1059
• insert_date: 20240808
• index_terms:
  • ieee_terms:
    • Fluorescence
    • Imaging
    • Immune system
    • Wireless sensor networks
    • Wireless communication
    • Cancer
    • Tumors
  • author_terms:
    • Biomedical implant
    • fluorescence imaging
    • immunotherapy
    • personalized medicine
    • ultrasound (US) energy harvesting
  • dynamic_index_terms:
    • Image Sensor
    • Camera Sensor
    • Multicolor Imaging
    • Food And Drug Administration
    • Effector Cells
    • Backscatter
    • Power Density
    • Energy Harvesting
    • Bit Error Rate
    • Bit Error Ratio
    • Immune Effector Cells
    • Bit Error
    • Fluorescence Images Of Cells
    • Immune Suppressive Cells
    • Inhibition Of Immune Cells
    • Pixel Array
    • Interference Filter
    • Ultrasound Power
    • Dual-color Imaging
    • Exposure Time
    • Immune Checkpoint Inhibitors
    • State Machine
    • Finite-state
    • Finite State Machine
    • Power Transfer
    • Charge Pump
    • Ultrasound Pulses
    • Dark Images
    • Wireless Power Transfer
    • Beam Power
    • Wireless Energy Transfer
    • Forward Bias
    • Forward Voltage
    • Capacitor Size
    • Acoustic Power
    • Implantable Sensors
    • Lead Zirconate Titanate
• authors:
  • Author Name: Micah Roschelle
    Affiliation: Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37089189089
    ID: 37089189089
    Order: 1
    Author Affiliations:
    • Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
  • Author Name: Rozhan Rabbani
    Affiliation: Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37086440695
    ID: 37086440695
    Order: 2
    Author Affiliations:
    • Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
  • Author Name: Surin Gweon
    Affiliation: Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37086698543
    ID: 37086698543
    Order: 3
    Author Affiliations:
    • Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
  • Author Name: Rohan Kumar
    Affiliation: Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37088968307
    ID: 37088968307
    Order: 4
    Author Affiliations:
    • Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
  • Author Name: Alec Vercruysse
    Affiliation: Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37089624071
    ID: 37089624071
    Order: 5
    Author Affiliations:
    • Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
  • Author Name: Nam Woo Cho
    Affiliation: Department of Radiation Oncology, Department of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/617927144795436
    ID: 617927144795436
    Order: 6
    Author Affiliations:
    • Department of Radiation Oncology, Department of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, CA, USA
  • Author Name: Matthew H. Spitzer
    Affiliation: Department of Otolaryngology-Head and Neck Surgery, Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/433638056316193
    ID: 433638056316193
    Order: 7
    Author Affiliations:
    • Department of Otolaryngology-Head and Neck Surgery, Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA, USA
  • Author Name: Ali M. Niknejad
    Affiliation: Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37280807800
    ID: 37280807800
    Order: 8
    Author Affiliations:
    • Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
  • Author Name: Vladimir M. Stojanović
    Affiliation: Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37283724300
    ID: 37283724300
    Order: 9
    Author Affiliations:
    • Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA, USA
  • Author Name: Mekhail Anwar
    Affiliation: Department of Radiation Oncology, Department of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37085394272
    ID: 37085394272
    Order: 10
    Author Affiliations:
    • Department of Radiation Oncology, Department of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, CA, USA
    • Department of Radiation Oncology, University of California at San Francisco, San Francisco, CA, USA

Image Sensor

• sensor_type: CMOS
• resolution: 36x40 pixels
• dynamic_range: Not specified
• pixel_size: 55µm
• dark_current: 14.9 fA (7.7 aA/µm²)

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: 2x2.2mm
• distortion: Not specified

Performance Metrics

• frame_rate: 13 kb/s (data rate)
• signal_to_noise_ratio: 20 dB (target SNR)
• sensitivity: 0.21 A/W at 650 nm
• shutter_speed: 8 ms (TEXP)
• power_consumption: 221 mW/cm² (US power flux density)
• noise: 5.34 mV rms for a single frame, 1.87 mV rms after 8 averages

Applications & Benefits

• cell_imaging: Wireless multicolor fluorescence imaging for real-time monitoring of cellular interactions, especially in cancer immunotherapy
• benefits: Enables monitoring of therapeutic response and resistance in cancer treatments, guiding personalized medicine.

Supporting Organizations

• supported_by: Office of the Director and the National Institute of Dental and Craniofacial Research of the National Institutes of Health, John V. Carbone Jr. Pancreatic Cancer Research Memorial Fund, Zaidi Family Gift Fund.

Manuscript Details

• publication_date: Nov. 2024

Relevancy Score

• score: 10

Processed JSON Filename

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