A Proton Camera Array Technology For Direct Extracellular Ion Imaging

• doi: 10.1109/ISIE.2008.4677310
• title: A proton camera array technology for direct extracellular ion imaging
• publisher: IEEE
• isbn: 978-1-4244-1666-0
• issn: 2163-5145
• partnum: 08TH8980
• rank: 1252
• access_type: LOCKED
• content_type: Conferences
• abstract: The study of cellular function and response is essential for basic research and for applications in the fields of biomedicine and biotechnology. We have developed the first 256-pixel proton camera array for imaging the hydrogen ion activity of cells grown in vitro. The proton camera is an integrated sensor array technology, designed and fabricated in a standard commercial 0.35 mum complementary metal oxide semiconductor (CMOS) process. Each pixel uses a hydrogen ion sensitive field-effect transistor (ISFET) and has an area of 12.8 mum times 12.8 mum, leading to a total on-chip sensing area of 200 mum times 200 mum. After electrical matching, it is found that each ISFET pixel has a threshold voltage of -1 V with a convergence accuracy of less than 10 mV and a measured sensitivity of 46 mV/pH. A cell bioassay is performed to demonstrate that the proton camera array can successfully image changes in extracellular pH.
• article_number: 4677310
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4677310
• html_url: https://ieeexplore.ieee.org/document/4677310/
• abstract_url: https://ieeexplore.ieee.org/document/4677310/
• publication_title: 2008 IEEE International Symposium on Industrial Electronics
• conference_location: Cambridge, UK
• conference_dates: 30 June-2 July 2008
• publication_number: 4664822
• is_number: 4676877
• publication_year: 2008
• publication_date: 30 June-2 July 2008
• start_page: 2051
• end_page: 2055
• citing_paper_count: 11
• citing_patent_count: 74
• download_count: 275
• insert_date: 20081118
• index_terms:
  • ieee_terms:
    • Protons
    • Cameras
    • Extracellular
    • Sensor arrays
    • Biomedical imaging
    • Hydrogen
    • CMOS image sensors
    • Biotechnology
    • In vitro
    • Biosensors
  • dynamic_index_terms:
    • Direct Imaging
    • Extracellular Ion
    • Threshold Voltage
    • Sensor Array
    • Array Images
    • Array Tomography
    • Field Of Biotechnology
    • Field Of Bioengineering
    • Field Of Biomedicine
    • Electrolyte
    • Electrolysis
    • Current Source
    • Current Regulations
    • Double Layer
    • Increase In pH
    • Equilibrium Constant
    • Printed Circuit Board
    • Passivation Layer
    • Surface Passivation
    • Silicon Nitride
    • Individual Pixels
    • Gate Electrode
    • Basic Sites
    • Pixel Array
    • Point Of Zero Charge
    • Plasma-enhanced Chemical Vapor Deposition
    • PECVD
    • Pixel Column
    • Operational Amplifier
    • Op-amp
    • Dielectric Surface
    • Insulator Surface
    • Column Array
    • Iodoacetate
    • Transconductance
    • Conductive Transfer
• isbn_formats:
  • format: CD, value: 978-1-4244-1666-0, isbnType: New-2005
  • format: Print ISBN, value: 978-1-4244-1665-3, isbnType: New-2005
• authors:
  • Author Name: Mark J. Milgrew
    Affiliation: Department of Electronics and Electrical Engineering, University of Glasgow, Glasgow, UK
    Author URL: https://ieeexplore.ieee.org/author/37832424600
    ID: 37832424600
    Order: 1
    Author Affiliations:
    • Department of Electronics and Electrical Engineering, University of Glasgow, Glasgow, UK
  • Author Name: David R. S. Cumming
    Affiliation: Department of Electronics and Electrical Engineering, University of Glasgow, Glasgow, UK
    Author URL: https://ieeexplore.ieee.org/author/37276149400
    ID: 37276149400
    Order: 2
    Author Affiliations:
    • Department of Electronics and Electrical Engineering, University of Glasgow, Glasgow, UK

Image Sensor

• sensor_type: CMOS
• resolution: 256 pixels in a 16x16 arrangement
• dynamic_range: not specified
• pixel_size: 12.8 µm x 12.8 µm
• dark_current: not specified

Optical Data

• focal_length: not specified
• aperture: not specified
• field_of_view: not specified
• distortion: not specified

Performance Metrics

• sensitivity: 46 mV/pH (for pH sensing)

Applications & Benefits

• cell_imaging: Direct imaging of extracellular hydrogen ion concentration relevant for cellular studies and drug responses.
• benefits: Low-cost, non-invasive monitoring of cell physiology, potential for applications in biomedicine and biotechnology, including drug discovery and tissue engineering.

Supporting Organizations

• supported_by: University of Glasgow, Austria Micro Systems

Manuscript Details

• publication_date: 30 June-2 July 2008

Relevancy Score

• score: 10
• missing_fields:
  • dynamic_range
  • dark_current
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • frame_rate
  • signal_to_noise_ratio
  • shutter_speed
  • power_consumption
  • noise

Processed JSON Filename

request_2bc9f0d3-387c-4df2-9adc-f763fc608284-a_proton_camera_array_technology_for_direct_extracellular_ion_imaging.json