A Multimodal Sensing Device For Fluorescence Imaging And Electrical Potential Measurement Of Neural Activities In A Mouse Deep Brain

• doi: 10.1109/IEMBS.2009.5334461
• title: A multimodal sensing device for fluorescence imaging and electrical potential measurement of neural activities in a mouse deep brain
• publisher: IEEE
• isbn: 978-1-4244-3296-7
• issn: 1558-4615
• partnum: 09CH38071
• rank: 1179
• access_type: LOCKED
• content_type: Conferences
• abstract: We have developed a multimodal CMOS sensing device to detect fluorescence image and electrical potential for neural activities in a mouse deep brain. The device consists of CMOS image sensor with on-chip electrodes and excitation light sources, all of which are integrated on a polyimide substrate. The novel feature of this device is its embedded on-chip electrodes which are partially transmit incident light so that the whole image can be acquired by the sensor. We have demonstrated the CMOS sensor device successfully operates in hippocampus area of an anesthetized mouse.
• article_number: 5334461
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=5334461
• html_url: https://ieeexplore.ieee.org/document/5334461/
• abstract_url: https://ieeexplore.ieee.org/document/5334461/
• publication_title: 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
• conference_location: Minneapolis, MN, USA
• conference_dates: 3-6 Sept. 2009
• publication_number: 5307844
• is_number: 5332379
• publication_year: 2009
• publication_date: 3-6 Sept. 2009
• start_page: 5887
• end_page: 5890
• citing_paper_count: 1
• citing_patent_count: 15
• download_count: 168
• insert_date: 20091113
• index_terms:
  • ieee_terms:
    • Multimodal sensors
    • Fluorescence
    • Electric potential
    • Electric variables measurement
    • Mice
    • CMOS image sensors
    • Electrodes
    • Light sources
    • Polyimides
    • Image sensors
  • dynamic_index_terms:
    • Brain Activity
    • Neural Activity
    • Electrostatic Potential
    • Electric Potential
    • Multimodal Devices
    • Image Sensor
    • Camera Sensor
    • Excitation Light Source
    • Fabrication Process
    • Photodiode
    • Sensor Chip
    • Brain Surface
    • Fluorescent Beads
    • Pixel Array
    • Al Layer
    • Al Electrode
    • Near-infrared Spectrometer
• isbn_formats:
  • format: CD, value: 978-1-4244-3296-7, isbnType: New-2005
• authors:
  • Author Name: Jun Ohta
    Affiliation: Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278016600
    ID: 37278016600
    Order: 1
    Author Affiliations:
    • Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Ayato Tagawa
    Affiliation: Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37681789900
    ID: 37681789900
    Order: 2
    Author Affiliations:
    • Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Hiroki Minami
    Affiliation: Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37666420900
    ID: 37666420900
    Order: 3
    Author Affiliations:
    • Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Toshihiko Noda
    Affiliation: Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37401924800
    ID: 37401924800
    Order: 4
    Author Affiliations:
    • Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Kiyotaka Sasagawa
    Affiliation: Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37287324600
    ID: 37287324600
    Order: 5
    Author Affiliations:
    • Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Takashi Tokuda
    Affiliation: Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278027500
    ID: 37278027500
    Order: 6
    Author Affiliations:
    • Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Yumiko Hatanaka
    Affiliation: Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37667825600
    ID: 37667825600
    Order: 7
    Author Affiliations:
    • Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Yasuyuki Ishikawa
    Affiliation: Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37292335500
    ID: 37292335500
    Order: 8
    Author Affiliations:
    • Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Hideki Tamura
    Affiliation: Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37290561300
    ID: 37290561300
    Order: 9
    Author Affiliations:
    • Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Sadao Shiosaka
    Affiliation: Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37294918400
    ID: 37294918400
    Order: 10
    Author Affiliations:
    • Graduate School of Materials Science, JST, CREST, Nara Institute of Science and Technology, Ikoma, Nara, Japan

Image Sensor

• sensor_type: CMOS
• resolution: 450x2310
• dynamic_range: Not specified
• pixel_size: 7.5x7.5 µm
• dark_current: Not specified

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• frame_rate: 2 fps, 4 fps
• noise: Increasing noise with frame rate

Applications & Benefits

• cell_imaging: Simultaneous detection of fluorescence imaging and electrical potential measurement in deep brain regions.
• benefits: Enables real-time monitoring of neural activities.

Supporting Organizations

• supported_by: JST, CREST

Manuscript Details

• publication_date: 3-6 Sept. 2009

Relevancy Score

• score: 9
• missing_fields:
  • quantum efficiency
  • readout speed
  • noise sources
  • analog-to-digital conversion techniques
  • microlenses
  • on-chip colour filters
  • global or rolling shutters
  • backside illumination

Processed JSON Filename

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