A Micro Imaging Device For Measuring Neural Actvities In The Mouse Deep Brain With Minimal Invasiveness

• doi: 10.1109/BioCAS.2012.6418451
• title: A micro imaging device for measuring neural actvities in the mouse deep brain with minimal invasiveness
• publisher: IEEE
• isbn: 978-1-4673-2292-8
• issn: 2163-4025
• partnum: 12EX4809
• rank: 1170
• access_type: LOCKED
• content_type: Conferences
• abstract: This paper describes a micro imaging device that is implantable in a mouse deep brain with minimal invasiveness to measure neural activities through fluorescence. The device consists of a dedicated micro CMOS image sensor and LEDs to excite fluorophore on a flexible substrate. To minimize invasiveness when it is implanted into a mouse brain deeply, the size of the present device is much smaller than the previously developed one. The CMOS image sensor has pixels of 90 × 30 with the pixel size of 7.5 μm × 7.5 μm, and is coated on the top of the sensing area with color filter to cut off excitation light and to transmit only fluorescence. The width and the thickness of the device head is about 0.5 mm and 0.2 mm, respectively. Fundamental device characteristics and some experimental results using a mouse are demonstrated.
• article_number: 6418451
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6418451
• html_url: https://ieeexplore.ieee.org/document/6418451/
• abstract_url: https://ieeexplore.ieee.org/document/6418451/
• publication_title: 2012 IEEE Biomedical Circuits and Systems Conference (BioCAS)
• conference_location: Hsinchu, Taiwan
• conference_dates: 28-30 Nov. 2012
• publication_number: 6410528
• is_number: 6418223
• publication_year: 2012
• publication_date: 28-30 Nov. 2012
• start_page: 244
• end_page: 247
• citing_paper_count: 5
• citing_patent_count: 0
• download_count: 139
• insert_date: 20130124
• index_terms:
  • ieee_terms:
    • Light emitting diodes
    • Mice
    • Fluorescence
    • Substrates
    • CMOS image sensors
    • Needles
  • dynamic_index_terms:
    • Minimally Invasive
    • Imaging Device
    • Mouse Brain
    • Brains Of Mice
    • Neural Activity
    • Polyethylene Terephthalate
    • Dacron
    • Flexible Substrates
    • Excitation Light
    • Image Sensor
    • Camera Sensor
    • Device Size
    • Color Filter
    • Uniform Distribution
    • Brain Activity
    • Optical Fiber
    • Fiber-optic
    • Serine Protease
    • Image Area
    • Emission Peak
    • Brain Slices
    • Slice Preparation
    • Hippocampus Of Mice
    • Hippocampi Of Mice
    • Mouse Hippocampus
    • Printed Circuit Board
    • Polyimide
    • Device Surface
    • Device Thickness
    • Planar Type
    • Needle Type
    • Mouse Head
    • Heads Of Mice
    • Planar Devices
    • Emission Centers
• isbn_formats:
  • format: Online ISBN, value: 978-1-4673-2292-8, isbnType: New-2005
  • format: Print ISBN, value: 978-1-4673-2291-1, isbnType: New-2005
  • format: Electronic ISBN, value: 978-1-4673-2293-5, isbnType: New-2005
• authors:
  • Author Name: Jun Ohta
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278016600
    ID: 37278016600
    Order: 1
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Chikara Kitsumoto
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/38246739000
    ID: 38246739000
    Order: 2
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Toshihiko Noda
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37401924800
    ID: 37401924800
    Order: 3
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Kiyotaka Sasagawa
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37287324600
    ID: 37287324600
    Order: 4
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Takashi Tokuda
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278027500
    ID: 37278027500
    Order: 5
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Mayumi Motoyama
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/38235269700
    ID: 38235269700
    Order: 6
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Yasumi Ohta
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/38548426000
    ID: 38548426000
    Order: 7
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Takuma Kobayashi
    Affiliation: Research Institute of Traditional Asian Medicine, Kinki University, Sayama, Osaka, Japan
    Author URL: https://ieeexplore.ieee.org/author/38238706100
    ID: 38238706100
    Order: 8
    Author Affiliations:
    • Research Institute of Traditional Asian Medicine, Kinki University, Sayama, Osaka, Japan
  • Author Name: Yasuaki Ishikawa
    Affiliation: Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37279796900
    ID: 37279796900
    Order: 9
    Author Affiliations:
    • Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Sadao Shiosaka
    Affiliation: Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37294918400
    ID: 37294918400
    Order: 10
    Author Affiliations:
    • Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan

Image Sensor

• sensor_type: CMOS
• resolution: 90 x 30 pixels
• dynamic_range: Not specified
• pixel_size: 7.5 µm x 7.5 µm
• dark_current: Not specified

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• frame_rate: 4.7 fps

Applications & Benefits

• cell_imaging: The device can measure neural activities in the brain through fluorescence.
• benefits: The device minimizes invasiveness compared to previous implantable devices, enabling better observation of neural activities.

Supporting Organizations

• supported_by: Japan Science and Technology Agency (JST)

Manuscript Details

• publication_date: 28-30 Nov. 2012

Relevancy Score

• score: 10
• missing_fields:
  • dynamic_range
  • dark_current
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • signal_to_noise_ratio
  • sensitivity
  • shutter_speed
  • power_consumption
  • noise

Processed JSON Filename

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