A Largescale Multimodal Cmos Biosensor Array With 131072 Pixels And Codedivision Multiplexed Readout

• doi: 10.1109/LSSC.2021.3056515
• title: A Large-Scale Multimodal CMOS Biosensor Array With 131,072 Pixels and Code-Division Multiplexed Readout
• publisher: IEEE
• isbn:
• issn: 2573-9603
• rank: 761
• access_type: LOCKED
• content_type: Journals
• abstract: This letter presents a large-scale fully integrated multimodal sensor array for biological imaging. The 512×256 sensor array can perform spatially resolved electrochemical impedance spectroscopy (EIS) with switching frequencies up to 100 MHz, acquire multicolor optical images, and sense pH using titanium nitride (TiN) ion sensitive field effect transistors (ISFETs). The chip features code-division multiplexed (CDM) readout of groups of pixels simultaneously, enabling extended integration times at a given frame rate. The system is implemented in 180-nm CMOS with 9.5 μm × 11.5 μm pixels. Its overall fill factor is 57%, including peripheral control and readout circuits, yielding a widefield spatially resolved multimodal biosensing platform for advanced cell culture applications.
• article_number: 9345984
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=9345984
• html_url: https://ieeexplore.ieee.org/document/9345984/
• abstract_url: https://ieeexplore.ieee.org/document/9345984/
• publication_title: IEEE Solid-State Circuits Letters
• conference_location:
• conference_dates:
• publication_number: 8011414
• is_number: 9329187
• publication_year: 2021
• publication_date: 2021
• start_page: 48
• end_page: 51
• citing_paper_count: 21
• citing_patent_count: 0
• download_count: 1536
• insert_date: 20210203
• index_terms:
  • ieee_terms:
    • Impedance
    • Sensors
    • Sensor arrays
    • Optical imaging
    • Biomedical measurement
    • Optical variables measurement
    • Impedance measurement
  • author_terms:
    • Array
    • biosensor
    • cell culture
    • CMOS
    • dielectric spectroscopy
    • electrochemical
    • image sensor
    • impedance spectroscopy
    • ion sensitive field effect transistor (ISFET)
  • dynamic_index_terms:
    • Large-scale Array
    • Code Division
    • Code-division
    • Biosensor Array
    • Cell Culture
    • Co-culture
    • Optical Tomography
    • Optical Imaging
    • Frame Rate
    • Electrochemical Impedance Spectroscopy
    • Field-effect Transistors
    • Sensor Array
    • Fill Factor
    • Titanium Nitride
    • Readout Circuit
    • Multimodal Sensor
    • Cellular Metabolism
    • Cell Metabolism
    • Lysogeny Broth
    • Luria-Bertani Agar
    • LB Medium
    • LB Agar
    • Luria Broth
    • Luria-Bertani Broth
    • Optical Measurements
    • Potassium Phosphate Buffer
    • pH Measurements
    • Types Of Sensors
    • Electrochemical Impedance Spectroscopy Measurements
    • Time-division Multiplexing
    • Time Division Multiplexing
    • Time-division-multiplexing
• authors:
  • Author Name: Kangping Hu
    Affiliation: School of Engineering, Brown University, Providence, RI, USA
    Author URL: https://ieeexplore.ieee.org/author/37087111690
    ID: 37087111690
    Order: 1
    Author Affiliations:
    • School of Engineering, Brown University, Providence, RI, USA
  • Author Name: Christopher E. Arcadia
    Affiliation: School of Engineering, Brown University, Providence, RI, USA
    Author URL: https://ieeexplore.ieee.org/author/37086616752
    ID: 37086616752
    Order: 2
    Author Affiliations:
    • School of Engineering, Brown University, Providence, RI, USA
  • Author Name: Jacob K. Rosenstein
    Affiliation: School of Engineering, Brown University, Providence, RI, USA
    Author URL: https://ieeexplore.ieee.org/author/37945044700
    ID: 37945044700
    Order: 3
    Author Affiliations:
    • School of Engineering, Brown University, Providence, RI, USA

Image Sensor

• sensor_type: CMOS
• resolution: 512x256
• dynamic_range: Not specified
• pixel_size: 9.5µm x 11.5µm
• dark_current: Not specified

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• noise: Active area measures an effective noise floor of 0.7 aF rms.

Applications & Benefits

• cell_imaging: Designed for monitoring cell cultures, with multimodal capabilities including impedance and optical measurements.
• benefits: Offers spatially resolved imaging for biological applications, enabling monitoring of cell growth and metabolism.

Supporting Organizations

• supported_by: Defense Advanced Research Projects Agency (DARPA), National Science Foundation

Manuscript Details

• publication_date: 2021

Relevancy Score

• score: 9
• missing_fields:
  • dynamic_range
  • dark_current
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • frame_rate
  • signal_to_noise_ratio
  • sensitivity
  • shutter_speed
  • power_consumption

Processed JSON Filename

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