A High Sensitivity Chemiluminescencebased Cmos Image Biosensor For The Detection Of Human Interleukin 5 Il5

• doi: 10.1109/ICSENS.2012.6411100
• title: A high sensitivity chemiluminescence-based CMOS image biosensor for the detection of human interleukin 5 (IL-5)
• publisher: IEEE
• isbn: 978-1-4577-1765-9
• issn: 1930-0395
• partnum: 11CH38911
• rank: 1088
• access_type: LOCKED
• content_type: Conferences
• abstract: In this study, a CMOS image sensor that converts light intensity to digital image data was used to detect human interleukin 5 (IL-5). Although the application of CMOS image sensors to biosensors is well known, a more sensitive method is needed to detect molecules with very low concentrations such as cytokines. For this reason, we have used a chemiluminescence reaction to increase the sensitivity of sandwich immunoassay in CMOS image sensor. Another approach used to obtain a high sensitivity response was the pixel counting analysis. By using pixel counting analysis, much more detailed luminescence signals can be obtained. The detection sensitivity of IL-5 we obtained in our experimental measurements was evaluated up to 0.1 pg/mL.
• article_number: 6411100
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6411100
• html_url: https://ieeexplore.ieee.org/document/6411100/
• abstract_url: https://ieeexplore.ieee.org/document/6411100/
• publication_title: SENSORS, 2012 IEEE
• conference_location: Taipei, Taiwan
• conference_dates: 28-31 Oct. 2012
• publication_number: 6381733
• is_number: 6411021
• publication_year: 2012
• publication_date: 28-31 Oct. 2012
• start_page: 1
• end_page: 3
• citing_paper_count: 1
• citing_patent_count: 0
• download_count: 196
• insert_date: 20130117
• index_terms:
  • ieee_terms:
    • Immune system
    • Sensitivity
    • Biosensors
    • CMOS image sensors
    • CMOS integrated circuits
    • Humans
    • Surface treatment
  • dynamic_index_terms:
    • Image Sensor
    • Camera Sensor
    • Pixel Count
    • Sandwich Immunoassay
    • P-coumaric Acid
    • P-coumaroyl
    • 4-coumarate
    • Biotinylation
    • Biotin Labeled
    • Sensitivity Of The Sensor
    • Capture Antibody
    • Sensor Surface
    • Horseradish Peroxidase-conjugated Streptavidin
    • Streptavidin-conjugated Horseradish Peroxidase
• isbn_formats:
  • format: Online ISBN, value: 978-1-4577-1765-9, isbnType: New-2005
  • format: Print ISBN, value: 978-1-4577-1766-6, isbnType: New-2005
  • format: Electronic ISBN, value: 978-1-4577-1767-3, isbnType: New-2005
• authors:
  • Author Name: Hyou-Arm Joung
    Affiliation: Gwangju Institute of Science and Technology, Gwangju, KR
    Author URL: https://ieeexplore.ieee.org/author/37088501219
    ID: 37088501219
    Order: 1
    Author Affiliations:
    • Gwangju Institute of Science and Technology, Gwangju, KR
  • Author Name: Dong-Gu Hong
    Affiliation: Gwangju Institute of Science and Technology, Gwangju, KR
    Author URL: https://ieeexplore.ieee.org/author/792188109550756
    ID: 792188109550756
    Order: 2
    Author Affiliations:
    • Gwangju Institute of Science and Technology, Gwangju, KR
  • Author Name: Min-Gon Kim
    Affiliation: Gwangju Institute of Science and Technology, Gwangju, KR
    Author URL: https://ieeexplore.ieee.org/author/37085616936
    ID: 37085616936
    Order: 3
    Author Affiliations:
    • Gwangju Institute of Science and Technology, Gwangju, KR

Image Sensor

• sensor_type: CMOS
• resolution: 50000 pixels (assuming a measurement area of 0.45 mm² and pixel size of 9 μm²)
• dynamic_range: Not specified
• pixel_size: 9 μm²
• dark_current: Not specified

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• sensitivity: 0.1 pg/mL (for IL-5 detection)

Applications & Benefits

• cell_imaging: Used for detection of human cytokines in biosensor applications.
• benefits: High sensitivity detection of low-concentration biomolecules.

Supporting Organizations

• supported_by: Gwangju Institute of Science and Technology, National Research Foundation of Korea

Manuscript Details

• publication_date: 28-31 Oct. 2012

Relevancy Score

• score: 10
• missing_fields:
  • dynamic_range
  • dark_current
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • frame_rate
  • signal_to_noise_ratio
  • shutter_speed
  • power_consumption
  • noise

Processed JSON Filename

request_e4fc8d62-c745-4000-af67-66b182f3152d-a_high_sensitivity_chemiluminescencebased_cmos_image_biosensor_for_the_detection_of_human_interleukin_5_il5.json