A Dualsensing Cmos Array For Combined Impedanceph Detection Of Dna With Integrated Electric Field Manipulation

• doi: 10.1109/ISCAS51556.2021.9401548
• title: A Dual-Sensing CMOS Array for Combined Impedance-pH Detection of DNA with Integrated Electric Field Manipulation
• publisher: IEEE
• isbn: 978-1-7281-9201-7
• issn: 2158-1525
• rank: 705
• access_type: LOCKED
• content_type: Conferences
• abstract: We have developed a CMOS System-on-Chip capable of concurrent DNA detection and actuation towards ultrafast and accurate molecular diagnostics. The system relies on a sensor array to perform electrochemical imaging by combining potentiometric ion-sensitive field-effect transistor (ISFET) sensing with impedance spectroscopy to concurrently detect DNA molecules and protons generated during an amplification reaction at high resolution. The impedance sensing electrodes are also used to conduct DNA manipulation using dielectrophoresis (DEP), further improving performance. The system achieves a maximum electric field strength of 2.5MV/m, generated with an AC voltage input of 1.8V, which is suitable for a battery supplied portable device. The sensing system made of EIS and ISFET front-ends are implemented in 0.18 μm CMOS technology. The ISFET sensing system presents a readout sensitivity of up to 129 mV (with a gain of 15 dB) with programmable controlled gate voltage to compensate non-idealities. Lastly, the EIS system is able to detect an impedance up to 100 MO within a frequency range between 100Hz-100kHz, presenting a dynamic range of 84.1 dB. The integrated systems achieve dual sensing and actuation for electrochemical DNA sensing with improved performance.
• article_number: 9401548
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=9401548
• html_url: https://ieeexplore.ieee.org/document/9401548/
• abstract_url: https://ieeexplore.ieee.org/document/9401548/
• publication_title: 2021 IEEE International Symposium on Circuits and Systems (ISCAS)
• conference_location: Daegu, Korea
• conference_dates: 22-28 May 2021
• publication_number: 9401028
• is_number: 9401051
• publication_year: 2021
• publication_date: 22-28 May 2021
• start_page: 1
• end_page: 5
• citing_paper_count: 4
• citing_patent_count: 0
• download_count: 449
• insert_date: 20210427
• index_terms:
  • ieee_terms:
    • Sensitivity
    • DNA
    • Imaging
    • Sensors
    • System-on-chip
    • Impedance
    • Electric fields
  • author_terms:
    • Dielectrophoresis
    • Biochemical
    • DNA
    • ISFET
    • Electrochemcial Impedance Spectroscopy(EIS)
    • Electrochemical imaging
  • dynamic_index_terms:
    • Detection Of DNA
    • Diagnostic Accuracy
    • Diagnostic Tests
    • Molecular Diagnosis
    • Molecular Diagnostics
    • DNA Molecules
    • Impedance Spectroscopy
    • Electrochemical Impedance Spectroscopy
    • Electric Field Strength
    • Electric Intensity
    • Electric Field Intensity
    • Potentiometric
    • Complementary Metal Oxide Semiconductor Technology
    • Complementary Metal-oxide-semiconductor Technology
    • Concurrent Detection
    • Simulation Results
    • Low-pass
    • Low-pass Filter
    • Linear System
    • System Architecture
    • Chip Surface
    • Intensity Gradient
    • Interdigitated Electrodes
    • Electric Field Gradient
    • Transimpedance Amplifier
    • Combination Of pH
    • Impedance Magnitude
    • Feedback Resistor
    • Coherent Detection
• isbn_formats:
  • format: Print ISBN, value: 978-1-7281-9201-7, isbnType: New-2005
• authors:
  • Author Name: Zhengyu Wang
    Affiliation: the Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Institute of Biomedical Engineering, London, United Kingdom
    Author URL: https://ieeexplore.ieee.org/author/37088900024
    ID: 37088900024
    Order: 1
    Author Affiliations:
    • the Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Institute of Biomedical Engineering, London, United Kingdom
  • Author Name: Lewis Keeble
    Affiliation: the Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Institute of Biomedical Engineering, London, United Kingdom
    Author URL: https://ieeexplore.ieee.org/author/37087319532
    ID: 37087319532
    Order: 2
    Author Affiliations:
    • the Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Institute of Biomedical Engineering, London, United Kingdom
  • Author Name: Nicolas Moser
    Affiliation: the Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Institute of Biomedical Engineering, London, United Kingdom
    Author URL: https://ieeexplore.ieee.org/author/37085398603
    ID: 37085398603
    Order: 3
    Author Affiliations:
    • the Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Institute of Biomedical Engineering, London, United Kingdom
  • Author Name: Tor Sverre Lande
    Affiliation: Department of Informatics, University of Oslo, Oslo, Norway
    Author URL: https://ieeexplore.ieee.org/author/37284121100
    ID: 37284121100
    Order: 4
    Author Affiliations:
    • Department of Informatics, University of Oslo, Oslo, Norway
  • Author Name: Pantelis Georgiou
    Affiliation: the Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Institute of Biomedical Engineering, London, United Kingdom
    Author URL: https://ieeexplore.ieee.org/author/37302145800
    ID: 37302145800
    Order: 5
    Author Affiliations:
    • the Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Institute of Biomedical Engineering, London, United Kingdom

Image Sensor

• sensor_type: CMOS
• resolution: Not specified
• dynamic_range: 84.1 dB
• pixel_size: 50 µm x 50 µm
• dark_current: 38.95 nA RMS

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• power_consumption: 20 mW (single pixel)
• noise: 38.95 nA RMS

Applications & Benefits

• cell_imaging: The CMOS system is capable of integrating DNA sensing and actuation in a portable device for rapid diagnostics.
• benefits: Improves DNA detection speed and accuracy, suitable for point-of-care applications.

Supporting Organizations

• supported_by: Imperial College London, University of Oslo

Manuscript Details

• publication_date: 22-28 May 2021

Relevancy Score

• score: 10
• missing_fields:
  • fill factor
  • quantum efficiency
  • readout speed
  • noise sources
  • analog-to-digital conversion techniques
  • microlenses
  • on-chip colour filters
  • global or rolling shutters
  • backside illumination

Processed JSON Filename

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