A Compact Halleffect Sensor Array For The Detection And Imaging Of Single Magnetic Beads In Biomedical Assays

• doi: 10.1109/TRANSDUCERS.2011.5969355
• title: A compact Hall-effect sensor array for the detection and imaging of single magnetic beads in biomedical assays
• publisher: IEEE
• isbn: 978-1-4577-0155-9
• issn: 2159-547X
• partnum: 11TH9206
• rank: 1023
• access_type: LOCKED
• content_type: Conferences
• abstract: A 64-unit Hall-effect sensor array capable of detecting magnetic beads is implemented in 0.18 μm CMOS process. Two Hall sensor implementations, one using n-wells and another using MOS transistors, are analyzed. The n-well implementation can detect a single 4.5 μm bead in .5 ms with a probability of error below 1% while the MOS implementation takes 2.5 ms to detect the same bead. Each array is compact so that individual beads can be detected and counted even if they do not land directly over a sensor. As a result, the array is capable of imaging magnetic beads, much like a digital camera, and thereby provides information about their individual locations and distribution.
• article_number: 5969355
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=5969355
• html_url: https://ieeexplore.ieee.org/document/5969355/
• abstract_url: https://ieeexplore.ieee.org/document/5969355/
• publication_title: 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference
• conference_location: Beijing, China
• conference_dates: 5-9 June 2011
• publication_number: 5958191
• is_number: 5969118
• publication_year: 2011
• publication_date: 5-9 June 2011
• start_page: 1833
• end_page: 1836
• citing_paper_count: 19
• citing_patent_count: 0
• download_count: 1049
• insert_date: 20110801
• index_terms:
  • ieee_terms:
    • Arrays
    • Magnetic resonance imaging
    • Wires
    • CMOS integrated circuits
    • Pixel
    • Magnetic separation
    • Sensitivity
  • author_terms:
    • Hall-effect
    • magnetic bead
    • biosensor
    • CMOS
  • dynamic_index_terms:
    • Magnetic Nanoparticles
    • Magnetic Beads
    • Sensor Array
    • Hall Sensor
    • Hall Effect Sensor
    • Error Probability
    • Hall Effect
    • Hall Current
    • Hall Angle
    • Hall Voltage
    • CMOS Process
    • Μm Beads
    • Individual Beads
    • Implementation Of Sensors
    • Magnetic Field
    • Relative Permeability
    • Magnetic Permeability
    • Permeability Of Space
    • Thermal Noise
    • Current Noise
    • Metal Layer
• isbn_formats:
  • format: CD, value: 978-1-4577-0155-9, isbnType: New-2005
  • format: Print ISBN, value: 978-1-4577-0157-3, isbnType: New-2005
  • format: Electronic ISBN, value: 978-1-4577-0156-6, isbnType: New-2005
• authors:
  • Author Name: K. Skucha
    Affiliation: University of California Berkeley, Berkeley, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37946024700
    ID: 37946024700
    Order: 1
    Author Affiliations:
    • University of California Berkeley, Berkeley, CA, USA
  • Author Name: P. Liu
    Affiliation: University of California Berkeley, Berkeley, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37959727500
    ID: 37959727500
    Order: 2
    Author Affiliations:
    • University of California Berkeley, Berkeley, CA, USA
  • Author Name: M. Megens
    Affiliation: University of California Berkeley, Berkeley, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37299217300
    ID: 37299217300
    Order: 3
    Author Affiliations:
    • University of California Berkeley, Berkeley, CA, USA
  • Author Name: J. Kim
    Affiliation: University of California Berkeley, Berkeley, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37966223700
    ID: 37966223700
    Order: 4
    Author Affiliations:
    • University of California Berkeley, Berkeley, CA, USA
  • Author Name: B. Boser
    Affiliation: University of California Berkeley, Berkeley, CA, USA
    Author URL: https://ieeexplore.ieee.org/author/37282431400
    ID: 37282431400
    Order: 5
    Author Affiliations:
    • University of California Berkeley, Berkeley, CA, USA

Image Sensor

• sensor_type: Hall-effect sensor
• resolution: Not specified for imaging resolution
• dynamic_range: Not specified
• pixel_size: 4x4 µm²
• dark_current: Not specified

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• signal_to_noise_ratio: Maximum SNR for n-well 23 dB; MOS 17 dB
• sensitivity: Bias current n-well 2.1 mA, MOS 0.7 mA
• shutter_speed: Not applicable (no shutter specifications found)
• power_consumption: Energy per detection n-well 2.1 µJ, MOS 3.5 µJ
• noise: Min. SNR n-well 14 dB; MOS 14 dB

Applications & Benefits

• cell_imaging: Detection and imaging of superparamagnetic microbeads used in biomedical assays
• benefits: Integration with microfluidics, low cost, compact size, ability to read out many sensors quickly for point-of-care applications

Supporting Organizations

• supported_by: trans-NIH Genes, Environment and Health Initiative, Biological Response Indicators of Environmental Systems Center grant U54 ES016115-01

Manuscript Details

• publication_date: 5-9 June 2011

Relevancy Score

• score: 4
• missing_fields:
  • fill factor
  • quantum efficiency
  • noise sources
  • readout speed
  • microlenses
  • on-chip colour filters
  • global or rolling shutters
  • backside illumination

Processed JSON Filename

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