A Cmos Sensor For Invivo Fluorescence And Electrical Imaging In A Mouse Brain

• doi: 10.1109/BIOCAS.2009.5372089
• title: A CMOS sensor for in-vivo fluorescence and electrical imaging in a mouse brain
• publisher: IEEE
• isbn: 978-1-4244-4918-7
• issn: 2163-4025
• partnum: 09EX3949
• rank: 642
• access_type: LOCKED
• content_type: Conferences
• abstract: We report a complementary-metal-oxide-semiconductor (CMOS) image sensor for in-vivo imaging. The sensor is implemented on a flexible substrate with LEDs as excitation light sources. The images are successfully obtained in a mouse brain. We demonstrate a image contrast improvement method on the basis of image processing and multiple readout in order to overcome non uniform illumination of the excitation light.
• article_number: 5372089
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=5372089
• html_url: https://ieeexplore.ieee.org/document/5372089/
• abstract_url: https://ieeexplore.ieee.org/document/5372089/
• publication_title: 2009 IEEE Biomedical Circuits and Systems Conference
• conference_location: Beijing, China
• conference_dates: 26-28 Nov. 2009
• publication_number: 5361057
• is_number: 5372018
• publication_year: 2009
• publication_date: 26-28 Nov. 2009
• start_page: 45
• end_page: 48
• citing_paper_count: 0
• citing_patent_count: 0
• download_count: 140
• insert_date: 20091231
• index_terms:
  • ieee_terms:
    • CMOS image sensors
    • Fluorescence
    • Mice
    • Brain
    • Image sensors
    • Sensor arrays
    • Light emitting diodes
    • High-resolution imaging
    • Magnetic resonance imaging
    • Materials science and technology
  • dynamic_index_terms:
    • Mouse Brain
    • Brains Of Mice
    • Complementary Metal Oxide Semiconductor Sensor
    • In-vivo Fluorescence
    • In-vivo Fluorescence Imaging
    • Light Source
    • Image Contrast
    • Polyethylene Terephthalate
    • Dacron
    • Flexible Substrates
    • Excitation Light
    • Improved Method
    • Improvement Of Methods
    • Image Sensor
    • Camera Sensor
    • Preclinical Imaging
    • Small Animal Imaging
    • In-vivo Imaging
    • Excitation Light Source
    • Brain Tissue
    • Human Brain
    • Green Fluorescent Protein
    • Contrast Agent
    • Contrast Enhancement
    • Contrast Medium
    • Neural Activity
    • Basal Ganglia
    • Optical Power
    • Lens Power
    • Refractive Power
    • Polyimide
    • Treatment Of Neurological Disorders
    • Treatment Of Neurological Diseases
    • Fluorescent Beads
    • Dark Areas
    • Background Image
    • Elucidation Of Functions
    • Higher Brain Functions
• isbn_formats:
  • format: CD, value: 978-1-4244-4918-7, isbnType: New-2005
  • format: Print ISBN, value: 978-1-4244-4917-0, isbnType: New-2005
• authors:
  • Author Name: Kiyotaka Sasagawa
    Affiliation: CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    Author URL: https://ieeexplore.ieee.org/author/37287324600
    ID: 37287324600
    Order: 1
    Author Affiliations:
    • CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Ayato Tagawa
    Affiliation: CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    Author URL: https://ieeexplore.ieee.org/author/37681789900
    ID: 37681789900
    Order: 2
    Author Affiliations:
    • CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Hiroki Minami
    Affiliation: CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    Author URL: https://ieeexplore.ieee.org/author/37666420900
    ID: 37666420900
    Order: 3
    Author Affiliations:
    • CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Masahiro Mitani
    Affiliation: CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    Author URL: https://ieeexplore.ieee.org/author/37088628947
    ID: 37088628947
    Order: 4
    Author Affiliations:
    • CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Toshihiko Noda
    Affiliation: CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    Author URL: https://ieeexplore.ieee.org/author/37401924800
    ID: 37401924800
    Order: 5
    Author Affiliations:
    • CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Takashi Tokuda
    Affiliation: CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278027500
    ID: 37278027500
    Order: 6
    Author Affiliations:
    • CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Hideki Tamura
    Affiliation: CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    Author URL: https://ieeexplore.ieee.org/author/37290561300
    ID: 37290561300
    Order: 7
    Author Affiliations:
    • CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    • Graduate School of Biological Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Yumiko Hatanaka
    Affiliation: CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    Author URL: https://ieeexplore.ieee.org/author/37667825600
    ID: 37667825600
    Order: 8
    Author Affiliations:
    • CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    • Graduate School of Biological Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Yasuyuki Ishikawa
    Affiliation: CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    Author URL: https://ieeexplore.ieee.org/author/37292335500
    ID: 37292335500
    Order: 9
    Author Affiliations:
    • CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    • Graduate School of Biological Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Sadao Shiosaka
    Affiliation: CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    Author URL: https://ieeexplore.ieee.org/author/37294918400
    ID: 37294918400
    Order: 10
    Author Affiliations:
    • CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    • Graduate School of Biological Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
  • Author Name: Jun Ohta
    Affiliation: CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278016600
    ID: 37278016600
    Order: 11
    Author Affiliations:
    • CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan

Image Sensor

• sensor_type: CMOS
• resolution: 120x266
• dynamic_range: Not specified
• pixel_size: 7.5μm x 7.5μm
• dark_current: Not specified

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• frame_rate: < 20 fps

Applications & Benefits

• cell_imaging: Used for in-vivo imaging of mouse brain
• benefits: Real-time fluorescent imaging for neural activity observation and potential applications in higher brain function studies and neurological disease treatment.

Supporting Organizations

• supported_by: Japan Science and Technology Agency, Semiconductor Technology Academic Research Center, Core Research for Evolutional Science and Technology (CREST), VLSI Design and Education Center, University of Tokyo

Manuscript Details

• publication_date: 26-28 Nov. 2009

Relevancy Score

• score: 10
• missing_fields:
  • dynamic_range
  • dark_current
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • signal_to_noise_ratio
  • sensitivity
  • shutter_speed
  • power_consumption
  • noise

Processed JSON Filename

request_071defab-58bd-4b78-bfb6-a2cab93d8d09-a_cmos_sensor_for_invivo_fluorescence_and_electrical_imaging_in_a_mouse_brain.json