A Cmos Opticalpotential Image Sensor With 75 M Pixel Size For Onchip Neural And Dna Spot Sensing

• doi: 10.1109/IEMBS.2005.1616189
• title: A CMOS optical/potential image sensor with 7.5 μm pixel size for on-chip neural and DNA spot sensing
• publisher: IEEE
• isbn: 0-7803-8741-4
• issn: 1558-4615
• rank: 635
• access_type: LOCKED
• content_type: Conferences
• abstract: An optical/potential CMOS image sensor was designed and fabricated for bioimaging applications. The image sensor is capable to simultaneously sense an optical image and an on-chip potential image. Target applications of the sensor are on-chip (optical + potential) neural imaging and on-chip DNA microarray sensing. The sensor has a QCIF (176 × 144) pixel array with alternatively aligned optical/potential sensing pixels. The pixel size is 7.5 μm × 7.5 μm. The potential resolution is confirmed to be better than 10 mV. An on-chip fluorescence imaging of a mouse's hippocampus was performed to demonstrate that fluorescence imaging is possible with on-chip configuration.
• article_number: 1616189
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=1616189
• html_url: https://ieeexplore.ieee.org/document/1616189/
• abstract_url: https://ieeexplore.ieee.org/document/1616189/
• publication_title: 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference
• conference_location: Shanghai, China
• conference_dates: 17-18 Jan. 2006
• publication_number: 10755
• is_number: 33900
• publication_year: 2005
• publication_date: 17-18 Jan. 2006
• start_page: 7269
• end_page: 7272
• citing_paper_count: 2
• citing_patent_count: 16
• download_count: 141
• insert_date: 20060410
• index_terms:
  • ieee_terms:
    • CMOS image sensors
    • Optical sensors
    • Image sensors
    • Pixel
    • DNA
    • Biomedical optical imaging
    • Optical imaging
    • Sensor arrays
    • Biosensors
    • Optical arrays
  • dynamic_index_terms:
    • Image Sensor
    • Camera Sensor
    • On-chip DNA
    • Optical Tomography
    • Optical Imaging
    • PCR Array
    • DNA Microarray
    • Gene Array
    • Hippocampus Of Mice
    • Hippocampi Of Mice
    • Mouse Hippocampus
    • Pixel Array
    • Neural Image
    • Circuitry
    • Excitation Light
    • Analog-to-digital Converter
    • Analog-to-digital
    • Digital-to-analog Converter
    • Sensor Surface
    • Sensor Characteristics
    • Sensor Features
    • Capacitive Coupling
    • AC-coupled
    • Electrostatic Coupling
    • Filters In Layer
    • Filters In Each Layer
    • Transmission Images
    • Color Filter
    • Sensor Pixel
    • Conductivity Probe
• isbn_formats:
  • format: Print ISBN, value: 0-7803-8741-4, isbnType: Historical
• authors:
  • Author Name: T. Tokuda
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278027500
    ID: 37278027500
    Order: 1
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
  • Author Name: D.C. Ng
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278114700
    ID: 37278114700
    Order: 2
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
  • Author Name: A. Yamamoto
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/38043315300
    ID: 38043315300
    Order: 3
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
  • Author Name: K. Kagawa
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278023200
    ID: 37278023200
    Order: 4
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
  • Author Name: M. Nunoshita
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37278019400
    ID: 37278019400
    Order: 5
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
  • Author Name: Jun Ohta
    Affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan
    Author URL: https://ieeexplore.ieee.org/author/37087173366
    ID: 37087173366
    Order: 6
    Author Affiliations:
    • Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan

Image Sensor

• sensor_type: CMOS
• resolution: QCIF (176 x 144)
• dynamic_range: Not specified
• pixel_size: 7.5 µm x 7.5 µm
• dark_current: Not specified

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• frame_rate: 1-10 fps
• noise: Temporal fluctuation smaller than 2 in pixel value.

Applications & Benefits

• cell_imaging: On-chip fluorescence imaging of a mouse's hippocampus was demonstrated successfully.
• benefits: Simultaneous sensing of optical and potential images for neural imaging and DNA microarray sensing.

Supporting Organizations

• supported_by: Industrial Technology Research Grant Program in ’04 from NEDO of Japan, Grant-in-Aid #16360175, #16650108 from Japanese Ministry of Education, Science, Sports and Culture.

Manuscript Details

• publication_date: 17-18 Jan. 2006

Relevancy Score

• score: 9
• missing_fields:
  • fill factor
  • quantum efficiency
  • readout speed
  • noise sources (including temporal noise and fixed-pattern noise)
  • analog-to-digital conversion techniques
  • microlenses
  • global or rolling shutters
  • backside illumination

Processed JSON Filename

request_27e77836-be30-4c56-be7a-68b5a3634de6-a_cmos_opticalpotential_image_sensor_with_75_m_pixel_size_for_onchip_neural_and_dna_spot_sensing.json