A Cmos Multisensor Array For High Accuracy Onchip Bacterial Growth Monitoring

• doi: 10.1109/ISCAS45731.2020.9180794
• title: A CMOS Multi-Sensor Array for High Accuracy On-Chip Bacterial Growth Monitoring
• publisher: IEEE
• isbn: 978-1-7281-3320-1
• issn: 2158-1525
• rank: 570
• access_type: LOCKED
• content_type: Conferences
• abstract: The existing CMOS platforms monitor the bacterial growth using single mode sensor and the bacteria samples are prepared separately which cause unreliable sensing results and potential contamination. In this paper, we present a CMOS multi-sensor array features high sensitive hydrogen ion, optical sensing and temperature modulation capability for accurate on-chip bacterial growth monitoring. A novel high sensitive hydrogen ion sensor and image sensor are integrated with an in-pixel capacitive transimpedance instrumentation amplifier (CTIA) to achieve both pH and optical sensing functionalities. The temperature modulation for on-chip bacteria culturing is realized through temperature sensor, heater and control circuit. A column SAR-Single Slope dual-mode ADC is employed, considering a quantization speed, chip area compromise and its compatibility with correlative double sampling. A state-of-the-art pH sensitivity of 217mV/pH is achieved in simulation. The high sensitive and multi-sensing features also make this sensing platform a promising candidate for antibiotic study, DNA sequencing, etc.
• article_number: 9180794
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=9180794
• html_url: https://ieeexplore.ieee.org/document/9180794/
• abstract_url: https://ieeexplore.ieee.org/document/9180794/
• publication_title: 2020 IEEE International Symposium on Circuits and Systems (ISCAS)
• conference_location: Seville, Spain
• conference_dates: 12-14 Oct 2020
• publication_number: 9179985
• is_number: 9180369
• publication_year: 2020
• publication_date: 12-14 Oct 2020
• start_page: 1
• end_page: 5
• citing_paper_count: 3
• citing_patent_count: 0
• download_count: 463
• insert_date: 20200928
• index_terms:
  • ieee_terms:
    • Temperature sensors
    • Microorganisms
    • Heating systems
    • Monitoring
    • Ions
    • Sensitivity
  • author_terms:
    • CMOS ion image sensor
    • image sensor
    • high sensitivity
    • SAR-SS ADC
    • bacterial growth monitoring
  • dynamic_index_terms:
    • Bacterial Growth
    • Multi-sensor Array
    • DNA Sequencing
    • Transition Temperature
    • Temperature Sensor
    • Image Sensor
    • Sensitivity Of The Sensor
    • Accurate Monitoring
    • Control Circuit
    • Chip Area
    • Sensitive Ion
    • Ion Sensors
    • High-sensitivity Sensor
    • Photodiode
    • Current Source
    • System Architecture
    • Analog-to-digital Converter
    • pH Variation
    • Analog Signal
    • Operational Amplifier
    • Reset Voltage
    • Readout Circuit
    • pH Monitoring
    • Hydrogen Ion Concentration
• isbn_formats:
  • format: Print ISBN, value: 978-1-7281-3320-1, isbnType: New-2005
• authors:
  • Author Name: Mingzheng Duan
    Affiliation: Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong, China
    Author URL: https://ieeexplore.ieee.org/author/37086038512
    ID: 37086038512
    Order: 1
    Author Affiliations:
    • Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong, China
  • Author Name: Xiaopeng Zhong
    Affiliation: Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong, China
    Author URL: https://ieeexplore.ieee.org/author/37085465484
    ID: 37085465484
    Order: 2
    Author Affiliations:
    • Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong, China
  • Author Name: Feng Gao
    Affiliation: College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar
    Author URL: https://ieeexplore.ieee.org/author/37086154885
    ID: 37086154885
    Order: 3
    Author Affiliations:
    • College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar
  • Author Name: Amine Bermak
    Affiliation: College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar
    Author URL: https://ieeexplore.ieee.org/author/37275353200
    ID: 37275353200
    Order: 4
    Author Affiliations:
    • College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar
  • Author Name: Yi-Kuen Lee
    Affiliation: Department of Mechanical and Aerospace Engineering, Hong Kong University of Science and Technology, Hong Kong, China
    Author URL: https://ieeexplore.ieee.org/author/37293395400
    ID: 37293395400
    Order: 5
    Author Affiliations:
    • Department of Mechanical and Aerospace Engineering, Hong Kong University of Science and Technology, Hong Kong, China

Image Sensor

• sensor_type: CMOS
• resolution: 40x21 pixels
• dynamic_range: Not specified
• pixel_size: 26um x 32um
• dark_current: Not specified

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• frame_rate: 2219 fps
• sensitivity: Highly sensitive hydrogen ion (217 mV/pH)

Applications & Benefits

• cell_imaging: Bacterial growth monitoring and potentially DNA sequencing.
• benefits: High accuracy monitoring, integrated pH, optical sensing, and temperature modulation.

Supporting Organizations

• supported_by: Hong Kong ITF funding, Guangdong Science and Technology grant, NPRP Grant from Qatar National Research Fund.

Manuscript Details

• publication_date: 12-14 Oct 2020

Relevancy Score

• score: 9
• missing_fields:
  • fill factor
  • quantum efficiency
  • readout speed
  • noise sources
  • analog-to-digital conversion techniques
  • microlenses
  • on-chip colour filters
  • global or rolling shutters
  • backside illumination

Processed JSON Filename

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