A Cmos Image Sensor For Dna Microarrays

• doi: 10.1109/CICC.2007.4405854
• title: A CMOS Image Sensor for DNA Microarrays
• publisher: IEEE
• isbn: 978-1-4244-1623-3
• issn: 2152-3630
• partnum: 07CH37853
• rank: 551
• access_type: LOCKED
• content_type: Conferences
• abstract: An image sensor designed with standard 0.18μm CMOS technology is used to construct a DNA microarray scanner. The detection limit of 4590 fluorophores/μm2 is compared with 4.49 fluorophores/μm2 of a commercial photomultiplier-tube-based microarray scanner. The performance gap can be reduced by improving optical coupling, mechanical alignment, laser power supply noise, improved circuit noise and an increase in the conversion gain. The CMOS sensor offers multiple-pixels for reduced scan time and an integrated analog-to-digital converter.
• article_number: 4405854
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4405854
• html_url: https://ieeexplore.ieee.org/document/4405854/
• abstract_url: https://ieeexplore.ieee.org/document/4405854/
• publication_title: 2007 IEEE Custom Integrated Circuits Conference
• conference_location: San Jose, CA, USA
• conference_dates: 16-19 Sept. 2007
• publication_number: 4405666
• is_number: 4405667
• publication_year: 2007
• publication_date: 16-19 Sept. 2007
• start_page: 821
• end_page: 824
• citing_paper_count: 9
• citing_patent_count: 6
• download_count: 257
• insert_date: 20080121
• index_terms:
  • ieee_terms:
    • CMOS image sensors
    • DNA
    • CMOS technology
    • Image sensors
    • Optical coupling
    • Laser noise
    • Power lasers
    • Power supplies
    • Noise reduction
    • Optical noise
  • dynamic_index_terms:
    • PCR Array
    • DNA Microarray
    • Gene Array
    • Image Sensor
    • Camera Sensor
    • Microarray Scanner
    • Optical Coupling
    • Optocoupler
    • Conversion Gain
    • Standard CMOS
    • CCD Camera
    • Charge-coupled Device
    • Fluorescence Emission
    • Photodetector
    • Emission Filter
    • Commercial Systems
    • Laser Source
    • Optical Power
    • Lens Power
    • Refractive Power
    • Photomultiplier Tube
    • Power Meter
    • Fast Scanning
    • Dark Current
    • CMOS Process
    • Differential Output
    • Differential Yield
    • Commercial Scanners
    • Optical Power Meter
    • Multiple Pixels
    • Transistor Size
    • Transistor Count
• isbn_formats:
  • format: CD, value: 978-1-4244-1623-3, isbnType: New-2005
  • format: Print ISBN, value: 978-1-4244-0786-6, isbnType: New-2005
• authors:
  • Author Name: Samir Parikh
    Affiliation: University of Toronto, Canada
    Author URL: https://ieeexplore.ieee.org/author/37288532800
    ID: 37288532800
    Order: 1
    Author Affiliations:
    • University of Toronto, Canada
  • Author Name: Glenn Gulak
    Affiliation: University of Toronto, Canada
    Author URL: https://ieeexplore.ieee.org/author/38556845900
    ID: 38556845900
    Order: 2
    Author Affiliations:
    • University of Toronto, Canada
  • Author Name: Paul Chow
    Affiliation: University of Toronto, Canada
    Author URL: https://ieeexplore.ieee.org/author/37266119000
    ID: 37266119000
    Order: 3
    Author Affiliations:
    • University of Toronto, Canada

Image Sensor

• sensor_type: CMOS
• resolution: Not specified
• dynamic_range: 74.63 dB
• pixel_size: 150µm x 150µm
• dark_current: 10 mV/sec

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• signal_to_noise_ratio: 16.6 dB @2.6 x 10^-2 lux
• sensitivity: < 2.6 x 10^-2 lux
• power_consumption: 26.4 mW

Applications & Benefits

• cell_imaging: Used for fluorescence-based detection of DNA in microarrays.
• benefits: Integrated ADC and potential for portability, faster scanning due to multiple pixels.

Supporting Organizations

• supported_by: CMC for semiconductor fabrication service; NSERC for Discovery Grant; University Health Network Microarray Centre for microarray slides; Institute of Optical Sciences for support and facilities.

Manuscript Details

• publication_date: 16-19 Sept. 2007

Relevancy Score

• score: 10
• missing_fields:
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • frame_rate
  • shutter_speed
  • noise

Processed JSON Filename

request_63b53cf0-6e15-44b3-8ebb-6a7148d4e4e8-a_cmos_image_sensor_for_dna_microarrays.json