A Biomedical Imaging System Based On An Integrated Array Of Magnetoresistive Sensors

• doi: 10.1109/NEWCAS50681.2021.9462751
• title: A Biomedical Imaging System Based on an Integrated Array of Magnetoresistive Sensors
• publisher: IEEE
• isbn: 978-1-6654-2430-1
• issn:
• rank: 524
• access_type: LOCKED
• content_type: Conferences
• abstract: Magnetic tunnel junctions (MTJs) provide a valuable platform for biomedical imaging applications especially if the sensors are built on top of a CMOS integrated circuit. In this paper, we devise a platform for readout of MTJs that rely on analog circuitry with relaxed specifications, while part of the system complexity is leveraged to digital post-processing. The proposed system comprises a high-density array of 64 × 64 MTJs that are readout by 4 acquisition channels which comprehend mismatch correction, amplification, filtering and data conversion. In order to handle the expected large spreads that result from fabrication mismatches in high-density MTJ arrays, we introduce a pre-calibration procedure that enhances the signal processing dynamic range, enabling the usage of medium performance electronics while leading to high-quality images even in the presence of weak magnetic fields. Finally, we discuss how a proper sampling strategy may lead to improved imaging noise performance, especially in regards to low-frequency (flicker) noise with virtually no drawbacks. A mathematical model is used to estimate the noise performance, which is contrasted to extensive transient noise simulations in a 180 nm commercial CMOS process and enable the assessment of the proposed techniques. We show that the proposed system is able to acquire each pixel with an input-referred noise of only 55 μV, while the input signal range in our application is only 2.34 mV.
• article_number: 9462751
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=9462751
• html_url: https://ieeexplore.ieee.org/document/9462751/
• abstract_url: https://ieeexplore.ieee.org/document/9462751/
• publication_title: 2021 19th IEEE International New Circuits and Systems Conference (NEWCAS)
• conference_location: Toulon, France
• conference_dates: 13-16 June 2021
• publication_number: 9462728
• is_number: 9462729
• publication_year: 2021
• publication_date: 13-16 June 2021
• start_page: 1
• end_page: 4
• citing_paper_count: 0
• citing_patent_count: 0
• download_count: 219
• insert_date: 20210625
• index_terms:
  • ieee_terms:
    • Semiconductor device modeling
    • Array signal processing
    • Magnetic sensors
    • Sensor systems
    • Mathematical model
    • Biosensors
    • Transient analysis
  • dynamic_index_terms:
    • Sensor Array
    • Magnetic Field
    • Dynamic Range
    • Biomedical Applications
    • Presence Of Magnetic Field
    • Input Range
    • Low-frequency Noise
    • Transient Simulation
    • Tunnel Junction
    • Flicker Noise
    • Acquisition Channels
    • Sample Set
    • Low-pass
    • Low-pass Filter
    • Denoising
    • Noise Reduction
    • Noise Sources
    • Lookup Table
    • Small Dimensions
    • Small Properties
    • Average Sample
    • Magnetic Particles
    • Single Sweep
    • Least Significant Bit
    • Low Bit
    • Binary Search
    • Sensor Output
    • Non-destructive Testing
    • Non-destructive Analysis
    • Non-destructive Evaluation
    • Sensor Selection
    • Output Filter
    • Noise Bandwidth
• isbn_formats:
  • format: Print on Demand(PoD) ISBN, value: 978-1-6654-2430-1, isbnType: New-2005
  • format: Electronic ISBN, value: 978-1-6654-2429-5, isbnType: New-2005
• authors:
  • Author Name: Taimur Rabuske
    Affiliation: INESC-ID, Instituto Superior Técnico, Universidade de Lisboa, Portugal
    Author URL: https://ieeexplore.ieee.org/author/38076213000
    ID: 38076213000
    Order: 1
    Author Affiliations:
    • INESC-ID, Instituto Superior Técnico, Universidade de Lisboa, Portugal
  • Author Name: Mário Silva
    Affiliation: INESC-ID, Instituto Superior Técnico, Universidade de Lisboa, Portugal
    Author URL: https://ieeexplore.ieee.org/author/37088896880
    ID: 37088896880
    Order: 2
    Author Affiliations:
    • INESC-ID, Instituto Superior Técnico, Universidade de Lisboa, Portugal
  • Author Name: Diogo Brito
    Affiliation: INESC-ID, Instituto Superior Técnico, Universidade de Lisboa, Portugal
    Author URL: https://ieeexplore.ieee.org/author/38547514800
    ID: 38547514800
    Order: 3
    Author Affiliations:
    • INESC-ID, Instituto Superior Técnico, Universidade de Lisboa, Portugal
  • Author Name: João Silva
    Affiliation: INESC-ID, Instituto Superior Técnico, Universidade de Lisboa, Portugal
    Author URL: https://ieeexplore.ieee.org/author/37086113110
    ID: 37086113110
    Order: 4
    Author Affiliations:
    • INESC-ID, Instituto Superior Técnico, Universidade de Lisboa, Portugal
  • Author Name: Hanna Iva Busse
    Affiliation: INESC-ID, Instituto Superior Técnico, Universidade de Lisboa, Portugal
    Author URL: https://ieeexplore.ieee.org/author/37088898803
    ID: 37088898803
    Order: 5
    Author Affiliations:
    • INESC-ID, Instituto Superior Técnico, Universidade de Lisboa, Portugal
  • Author Name: Ana V. Silva
    Affiliation: INESC-MN, Instituto Superior Técnico, Universidade de Lisboa, Portugal
    Author URL: https://ieeexplore.ieee.org/author/38489185800
    ID: 38489185800
    Order: 6
    Author Affiliations:
    • INESC-MN, Instituto Superior Técnico, Universidade de Lisboa, Portugal
  • Author Name: Sofia Abrunhosa
    Affiliation: INESC-MN, Instituto Superior Técnico, Universidade de Lisboa, Portugal
    Author URL: https://ieeexplore.ieee.org/author/37088897559
    ID: 37088897559
    Order: 7
    Author Affiliations:
    • INESC-MN, Instituto Superior Técnico, Universidade de Lisboa, Portugal
  • Author Name: Pedro Ribeiro
    Affiliation: INESC-MN, Instituto Superior Técnico, Universidade de Lisboa, Portugal
    Author URL: https://ieeexplore.ieee.org/author/37086026015
    ID: 37086026015
    Order: 8
    Author Affiliations:
    • INESC-MN, Instituto Superior Técnico, Universidade de Lisboa, Portugal
  • Author Name: Susana Cardoso
    Affiliation: INESC-MN, Instituto Superior Técnico, Universidade de Lisboa, Portugal
    Author URL: https://ieeexplore.ieee.org/author/37266515500
    ID: 37266515500
    Order: 9
    Author Affiliations:
    • INESC-MN, Instituto Superior Técnico, Universidade de Lisboa, Portugal

Image Sensor

• sensor_type: Magnetic Tunnel Junction (MTJ) sensors integrated with CMOS
• resolution: 64x64 pixels (4096 pixels total)
• dynamic_range: Approximately 2 mV
• pixel_size: 20x20 µm
• dark_current: Not specified

Optical Data

• focal_length: Not applicable
• aperture: Not applicable
• field_of_view: Not applicable
• distortion: Not applicable

Performance Metrics

• signal_to_noise_ratio: Not specified (input-referred noise: 55 µV)
• shutter_speed: Not applicable
• noise: Integrated noise of 55 µV, total integrated noise for single sweep is 46.27 mV and for multiple sweeps is 11.06 mV.

Applications & Benefits

• cell_imaging: The system is designed for detecting cells marked with magnetic particles on top of the MTJ array.
• benefits: The system allows high-resolution biomedical imaging, especially for low-frequency noise reduction in applications with small input signal ranges.

Supporting Organizations

• supported_by: FCT, European Union projects ECSEL, H2020

Manuscript Details

• publication_date: 13-16 June 2021

Relevancy Score

• score: 10

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