A 21952Pixel Multimodal Cmos Cellular Sensor Array With 1568Pixel Parallel Recording And 4Point Impedance Sensing

• doi: 10.23919/VLSIC.2019.8778043
• title: A 21952-Pixel Multi-Modal CMOS Cellular Sensor Array with 1568-Pixel Parallel Recording and 4-Point Impedance Sensing
• publisher: IEEE
• isbn: 978-1-7281-0914-5
• issn: 2158-5601
• rank: 361
• access_type: LOCKED
• content_type: Conferences
• abstract: This paper presents a fully integrated CMOS multi-modal cellular sensor/stimulator array with 21952 multi-modal pixels, 1568 simultaneous parallel readout channels, 16 μm×16 μm pixel pitch for single cell resolution, and 3.6 mm×1.6 mm tissue-level field-of-view (FoV), achieving high-resolution multi-parametric cellular potential/impedance/optical imaging for holistic cellular characterization and cell-based assays. Moreover, the array system reports the first on-chip true 4-point impedance sensing scheme with 16 parallel impedance sensing channels, which enables precise cellular impedance measurements with aggressively scaled electrodes and large electrode-electrolyte interfacial impedance. The chip also supports concurrent 16-channel 5-bit reconfigurable current-mode cell stimulation. The chip is implemented in a 130 nm low-cost standard CMOS process. Extracellular potentials (700 μV-1.5 mV) from on-chip cultured neonatal rat ventricular myocytes (NRVMs) are successfully measured. With on-chip cultured cardiac fibroblasts, full-chip high-resolution optical images and 4-point impedance mapping precisely capture cell distribution, growth, proliferation, and surface adhesion.
• article_number: 8778043
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8778043
• html_url: https://ieeexplore.ieee.org/document/8778043/
• abstract_url: https://ieeexplore.ieee.org/document/8778043/
• publication_title: 2019 Symposium on VLSI Circuits
• conference_location: Kyoto, Japan
• conference_dates: 9-14 June 2019
• publication_number: 8766307
• is_number: 8777931
• publication_year: 2019
• publication_date: 9-14 June 2019
• start_page: C62
• end_page: C63
• citing_paper_count: 10
• citing_patent_count: 0
• download_count: 840
• insert_date: 20190729
• index_terms:
  • ieee_terms:
    • Impedance
    • Optical imaging
    • Optical sensors
    • Current measurement
    • Fibroblasts
    • System-on-chip
  • dynamic_index_terms:
    • Parallel Recordings
    • Impedance Sensing
    • Optical Tomography
    • Optical Imaging
    • Cell-based Assays
    • Neonatal Rat Ventricular Myocytes
    • Current Stimulation
    • Potential Recordings
    • Multimodal Interaction
    • Multimodal Interface
    • Array Of Units
    • Time-division Multiplexing
    • Time Division Multiplexing
    • Time-division-multiplexing
    • Shadow Images
    • Clock Generator
    • Biphasic Stimulation
• isbn_formats:
  • format: Print on Demand(PoD) ISBN, value: 978-1-7281-0914-5, isbnType: New-2005
  • format: Electronic ISBN, value: 978-4-86348-720-8, isbnType: New-2005
• authors:
  • Author Name: Doohwan Jung
    Affiliation: Georgia Institute of Technology, Atlanta, GA, USA
    Author URL: https://ieeexplore.ieee.org/author/37086171376
    ID: 37086171376
    Order: 1
    Author Affiliations:
    • Georgia Institute of Technology, Atlanta, GA, USA
  • Author Name: Jong Seok Park
    Affiliation: Georgia Institute of Technology, Atlanta, GA, USA
    Author URL: https://ieeexplore.ieee.org/author/37076021200
    ID: 37076021200
    Order: 2
    Author Affiliations:
    • Georgia Institute of Technology, Atlanta, GA, USA
  • Author Name: Gregory V Junek
    Affiliation: Georgia Institute of Technology, Atlanta, GA, USA
    Author URL: https://ieeexplore.ieee.org/author/37086823091
    ID: 37086823091
    Order: 3
    Author Affiliations:
    • Georgia Institute of Technology, Atlanta, GA, USA
  • Author Name: Sandra I. Grijalva
    Affiliation: Emory University, Atlanta, GA, USA
    Author URL: https://ieeexplore.ieee.org/author/37086320854
    ID: 37086320854
    Order: 4
    Author Affiliations:
    • Emory University, Atlanta, GA, USA
  • Author Name: Sagar R Kumashi
    Affiliation: Georgia Institute of Technology, Atlanta, GA, USA
    Author URL: https://ieeexplore.ieee.org/author/37086918310
    ID: 37086918310
    Order: 5
    Author Affiliations:
    • Georgia Institute of Technology, Atlanta, GA, USA
  • Author Name: Adam Wang
    Affiliation: Georgia Institute of Technology, Atlanta, GA, USA
    Author URL: https://ieeexplore.ieee.org/author/37086820709
    ID: 37086820709
    Order: 6
    Author Affiliations:
    • Georgia Institute of Technology, Atlanta, GA, USA
  • Author Name: Sensen Li
    Affiliation: Georgia Institute of Technology, Atlanta, GA, USA
    Author URL: https://ieeexplore.ieee.org/author/37085668842
    ID: 37085668842
    Order: 7
    Author Affiliations:
    • Georgia Institute of Technology, Atlanta, GA, USA
  • Author Name: Hee Cheol Cho
    Affiliation: Emory University, Atlanta, GA, USA
    Author URL: https://ieeexplore.ieee.org/author/37085828404
    ID: 37085828404
    Order: 8
    Author Affiliations:
    • Emory University, Atlanta, GA, USA
  • Author Name: Hua Wang
    Affiliation: Georgia Institute of Technology, Atlanta, GA, USA
    Author URL: https://ieeexplore.ieee.org/author/37538488700
    ID: 37538488700
    Order: 9
    Author Affiliations:
    • Georgia Institute of Technology, Atlanta, GA, USA

Image Sensor

• sensor_type: CMOS
• resolution: 21952 pixels
• dynamic_range: not specified
• pixel_size: 16µm x 16µm
• dark_current: not specified

Optical Data

• focal_length: not specified
• aperture: not specified
• field_of_view: 3.6 mm x 1.6 mm
• distortion: not specified

Performance Metrics

• frame_rate: 3.84 x 10^3 frames/s
• signal_to_noise_ratio: 52 dB
• noise: 11µV rms (over 1 Hz-400 Hz), 3.7µV rms (over 401 Hz-2.3 kHz)

Applications & Benefits

• cell_imaging: Measurements of cellular potential, impedance, and optical imaging for cellular characterization; useful in drug development and assays.
• benefits: High-resolution, multi-parametric imaging suitable for a variety of applications including cell-based assays.

Supporting Organizations

• supported_by: Georgia Institute of Technology, Emory University

Manuscript Details

• publication_date: 9-14 June 2019

Relevancy Score

• score: 9
• missing_fields:
  • fill factor
  • quantum efficiency
  • readout speed
  • noise sources
  • analog-to-digital conversion techniques
  • use of microlenses
  • on-chip colour filters
  • global or rolling shutters
  • backside illumination

Processed JSON Filename

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