A 1616 Cmos Proton Camera Array For Direct Extracellular Imaging Of Hydrogenion Activity

• doi: 10.1109/ISSCC.2008.4523321
• title: A 16×16 CMOS Proton Camera Array for Direct Extracellular Imaging of Hydrogen-Ion Activity
• publisher: IEEE
• isbn: 978-1-4244-2011-7
• issn: 2376-8606
• partnum: 08CH37986
• rank: 321
• access_type: LOCKED
• content_type: Conferences
• abstract: Over the past twenty-five years, silicon CMOS technology has firmly established itself as the dominant platform in the microelectronics industry. This has resulted in many recent initiatives to fabricate CMOS-based microelectrodes for the stimulation and recording of electrical activity of neurons. CMOS technology offers the potential for monolithic integration of sensors and electronics and it serves as an appropriate platform to facilitate the integration of large arrays of sensors into a small geometry. The extracellular pH of a cell culture is a particularly important indicator of global cellular metabolism, but up until now, this property has typically been measured with invasive and expensive techniques such as miniaturized glass microelectrodes, fluorescent ratio imaging microscopy and magnetic resonance spectroscopy. CMOS provides a scalable, low cost, mass manufacturing platform, and offers the potential to develop sensor arrays that can perform non-invasive and long term imaging on cultured cells. In this paper, we present the first 16x16 proton camera array for direct imaging of the hydrogen-ion activity of cell cultures grown in vitro. The proton camera is based on a single-chip ion-sensitive field-effect transistor (ISFET) sensor array technology that can be implemented using a standard commercial CMOS process.
• article_number: 4523321
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4523321
• html_url: https://ieeexplore.ieee.org/document/4523321/
• abstract_url: https://ieeexplore.ieee.org/document/4523321/
• publication_title: 2008 IEEE International Solid-State Circuits Conference - Digest of Technical Papers
• conference_location: San Francisco, CA, USA
• conference_dates: 3-7 Feb. 2008
• publication_number: 4497158
• is_number: 4523032
• publication_year: 2008
• publication_date: 3-7 Feb. 2008
• start_page: 590
• end_page: 638
• citing_paper_count: 8
• citing_patent_count: 129
• download_count: 820
• insert_date: 20090304
• index_terms:
  • ieee_terms:
    • Protons
    • CMOS image sensors
    • Cameras
    • Extracellular
    • Sensor arrays
    • CMOS technology
    • Magnetic resonance imaging
    • Microelectrodes
    • Magnetic sensors
    • Silicon
  • dynamic_index_terms:
    • Actual Image
    • Direct Imaging
    • Electrode
    • Magnetic Resonance Spectroscopy
    • MR Spectroscopy
    • Linear Range
    • Current Source
    • Current Regulations
    • Printed Circuit Board
    • Threshold Voltage
    • Passivation Layer
    • Surface Passivation
    • Sensor Array
    • Individual Pixels
    • Basic Building Blocks
    • Plasma-enhanced Chemical Vapor Deposition
    • PECVD
    • CMOS Technology
    • Operational Amplifier
    • Op-amp
    • CMOS Process
    • Pixel Array
    • polySia
    • Polycrystalline Silicon
    • Polysilicon
    • Column Array
• isbn_formats:
  • format: CD, value: 978-1-4244-2011-7, isbnType: New-2005
  • format: Print ISBN, value: 978-1-4244-2010-0, isbnType: New-2005
• authors:
  • Author Name: Mark J. Milgrew
    Affiliation: University of Glasgow, Glasgow, UK
    Author URL: https://ieeexplore.ieee.org/author/37832424600
    ID: 37832424600
    Order: 1
    Author Affiliations:
    • University of Glasgow, Glasgow, UK
  • Author Name: Mathis O. Riehle
    Affiliation: University of Glasgow, Glasgow, UK
    Author URL: https://ieeexplore.ieee.org/author/37641898900
    ID: 37641898900
    Order: 2
    Author Affiliations:
    • University of Glasgow, Glasgow, UK
  • Author Name: David R. S. Cumming
    Affiliation: University of Glasgow, Glasgow, UK
    Author URL: https://ieeexplore.ieee.org/author/37276149400
    ID: 37276149400
    Order: 3
    Author Affiliations:
    • University of Glasgow, Glasgow, UK

Image Sensor

• sensor_type: CMOS
• resolution: 16x16 pixels
• dynamic_range: Unknown
• pixel_size: 12.8µm x 12.8µm
• dark_current: Unknown

Optical Data

• focal_length: Unknown
• aperture: Unknown
• field_of_view: Unknown
• distortion: Unknown

Performance Metrics

• frame_rate: Unknown
• signal_to_noise_ratio: Unknown
• sensitivity: Unknown
• shutter_speed: Unknown
• power_consumption: Unknown
• noise: Unknown

Applications & Benefits

• cell_imaging: Used for direct imaging of pH activity in cell cultures and monitoring cellular metabolism.
• benefits: Low-cost, non-invasive imaging of extracellular pH with long-term monitoring capabilities.

Supporting Organizations

• supported_by: EPSRC, austriamicrosystems

Manuscript Details

• publication_date: 3-7 Feb. 2008

Relevancy Score

• score: 10
• missing_fields:
  • dynamic_range
  • dark_current
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • frame_rate
  • signal_to_noise_ratio
  • sensitivity
  • shutter_speed
  • power_consumption
  • noise

Processed JSON Filename

request_1c05646b-9d5e-4010-9472-cec754ba48d1-a_1616_cmos_proton_camera_array_for_direct_extracellular_imaging_of_hydrogenion_activity.json