A 018Mu M Cmos Array Sensor For Integrated Timeresolved Fluorescence Detection

• doi: 10.1109/JSSC.2009.2016994
• title: A 0.18-$\mu$ m CMOS Array Sensor for Integrated Time-Resolved Fluorescence Detection
• publisher: IEEE
• isbn:
• issn: 1558-173X
• rank: 143
• access_type: LOCKED
• content_type: Journals
• abstract: This paper describes the design of an active, integrated CMOS sensor array for fluorescence applications which enables time-gated, time-resolved fluorescence spectroscopy. The 64-by-64 array is sensitive to photon densities as low as 8.8 times 106 photons/cm2 with 64-point averaging and, through a differential pixel design, has a measured impulse response of better than 800 ps. Applications include both active microarrays and high-frame-rate imagers for fluorescence lifetime imaging microscopy.
• article_number: 4907340
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4907340
• html_url: https://ieeexplore.ieee.org/document/4907340/
• abstract_url: https://ieeexplore.ieee.org/document/4907340/
• publication_title: IEEE Journal of Solid-State Circuits
• conference_location:
• conference_dates:
• publication_number: 4
• is_number: 4907307
• publication_year: 2009
• publication_date: May 2009
• start_page: 1644
• end_page: 1654
• citing_paper_count: 35
• citing_patent_count: 1
• download_count: 1099
• insert_date: 20090502
• index_terms:
  • ieee_terms:
    • Fluorescence
    • Sensor arrays
    • CMOS image sensors
    • Microscopy
    • Optical filters
    • Optoelectronic and photonic sensors
    • Detectors
    • Optical imaging
    • In vivo
    • In vitro
  • author_terms:
    • Biosensor
    • CMOS image sensor
    • fluorescence
    • microarray
  • dynamic_index_terms:
    • Sensor Array
    • Time-resolved Fluorescence
    • Impulse Response
    • Fluorescence Lifetime
    • Fluorescence Lifetime Imaging Microscopy
    • FLIM
    • Fluorescence Lifetime Imaging
    • Lifetime Imaging
    • Time-resolved Fluorescence Spectroscopy
    • Time Constant
    • Laser Pulse
    • Frame Rate
    • Large Capacity
    • Large Capacitance
    • Quantum Efficiency
    • Analog-to-digital Converter
    • Analog-to-digital
    • Digital-to-analog Converter
    • Excitation Source
    • Photomultiplier Tube
    • Voltage Difference
    • Voltage Deviation
    • Noise Floor
    • Transconductance
    • Conductive Transfer
    • Time-correlated Single-photon Counting
    • TCSPC
    • Quantization Noise
    • Input-referred Noise
    • Transimpedance Amplifier
    • Temporal Noise
    • Differential Amplifier
    • Clock Period
    • Characteristic Lifetime
    • Transient Photocurrent
    • Data Conversion
    • Conversational Data
    • Voltage Noise
    • Integration Period
• authors:
  • Author Name: Ta-chien D. Huang
    Affiliation: Columbia Bioelectronics Systems Laboratory, Department of Electrical Engineering, Columbia University, NY, USA
    Author URL: https://ieeexplore.ieee.org/author/37613192500
    ID: 37613192500
    Order: 1
    Author Affiliations:
    • Columbia Bioelectronics Systems Laboratory, Department of Electrical Engineering, Columbia University, NY, USA
  • Author Name: Sebastian Sorgenfrei
    Affiliation: Columbia Bioelectronics Systems Laboratory, Department of Electrical Engineering, Columbia University, NY, USA
    Author URL: https://ieeexplore.ieee.org/author/37643240900
    ID: 37643240900
    Order: 2
    Author Affiliations:
    • Columbia Bioelectronics Systems Laboratory, Department of Electrical Engineering, Columbia University, NY, USA
  • Author Name: Ping Gong
    Affiliation: Columbia Bioelectronics Systems Laboratory, Department of Electrical Engineering, Columbia University, NY, USA
    Author URL: https://ieeexplore.ieee.org/author/37633341400
    ID: 37633341400
    Order: 3
    Author Affiliations:
    • Columbia Bioelectronics Systems Laboratory, Department of Electrical Engineering, Columbia University, NY, USA
  • Author Name: Rastislav Levicky
    Affiliation: Department of Chemical and Biological Engineering, Polytechnic University, Brooklyn, NY, USA
    Author URL: https://ieeexplore.ieee.org/author/37422275800
    ID: 37422275800
    Order: 4
    Author Affiliations:
    • Department of Chemical and Biological Engineering, Polytechnic University, Brooklyn, NY, USA
  • Author Name: Kenneth L. Shepard
    Affiliation: Columbia Bioelectronics Systems Laboratory, Department of Electrical Engineering, Columbia University, NY, USA
    Author URL: https://ieeexplore.ieee.org/author/37273513800
    ID: 37273513800
    Order: 5
    Author Affiliations:
    • Columbia Bioelectronics Systems Laboratory, Department of Electrical Engineering, Columbia University, NY, USA

Image Sensor

• sensor_type: CMOS
• resolution: 64x64
• dynamic_range: Not specified
• pixel_size: 50 µm x 50 µm
• dark_current: Not specified

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• frame_rate: > 300 fps
• sensitivity: 21.3 e-/cm²
• noise: Temporal noise, fixed-pattern noise derived from sources specified in noise analysis.

Applications & Benefits

• cell_imaging: Fluorescence lifetime imaging microscopy (FLIM) and active microarray sensing for biomolecular detection.
• benefits: Time-gated operation enhances signal-to-background ratio (SBR) without needing external filters.

Supporting Organizations

• supported_by: National Human Genome Research Institute, National Science Foundation, NYSTAR, and C2S2 Focus Center Research Program.

Manuscript Details

• publication_date: May 2009

Relevancy Score

• score: 10

Processed JSON Filename

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