18F Autoradiography With The Mimosa28 Characterization And Application

• doi: 10.1109/TRPMS.2020.2996912
• title: 18F autoradiography With the Mimosa-28: Characterization and Application
• publisher: IEEE
• isbn:
• issn: 2469-7303
• rank: 30
• access_type: LOCKED
• content_type: Journals
• abstract: Autoradiography (AR) is a technique used to record the spatial distribution of a radiotracer into an ex-vivo tissue slice. Within the section, the radioactive molecules emit charged particles from specific binding sites. These particles pass through the tissue before being detected by a sensor. AR gives the distribution of a radioactive molecule with a spatial resolution of approximately one hundred microns. In this article, we investigated the feasibility of AR with a CMOS-APS sensor using radioactive isotope 18F. This sensor works in digital mode by collecting charges. It presents a linear response with isotope 18F for activity between 1 kBq and 1 MBq. The detection efficiency is 44,0 ± 0.5% for this range of activity with a spatial resolution of 144 ± 3 μm by using the absorber edge method. The Mimosa-28 sensor performs AR imaging with a rose leaf and a mouse brain section which has a thickness of 50 μm and an activity of 4 kBq in the slice.
• article_number: 9099203
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=9099203
• html_url: https://ieeexplore.ieee.org/document/9099203/
• abstract_url: https://ieeexplore.ieee.org/document/9099203/
• publication_title: IEEE Transactions on Radiation and Plasma Medical Sciences
• conference_location:
• conference_dates:
• publication_number: 7433213
• is_number: 9184290
• publication_year: 2020
• publication_date: Sept. 2020
• start_page: 630
• end_page: 636
• citing_paper_count: 1
• citing_patent_count: 0
• download_count: 100
• insert_date: 20200525
• index_terms:
  • ieee_terms:
    • Spatial resolution
    • Linearity
    • CMOS technology
    • Brain
    • Fluorine
    • Radiography
    • Active pixel sensors
  • author_terms:
    • Autoradiography (AR)
    • brain
    • complementary metal oxide semiconductor (CMOS) active pixel sensor (APS)
    • fluorine 18
  • dynamic_index_terms:
    • Spatial Resolution
    • Isotope
    • Brain Sections
    • Charged Particles
    • Digital Modulation
    • Mouse Brain Sections
    • Brain Sections Of Mice
    • Autoradiography Images
    • Impedance
    • Resistivity
    • Signal-to-noise
    • Signal-to-noise Ratio
    • Signal To Noise
    • Signal To Noise Ratio
    • Activation Function
    • Exposure Time
    • Optical Tomography
    • Optical Imaging
    • CCD Camera
    • Charge-coupled Device
    • Charge Coupled Device
    • Dynamic Range
    • Positron
    • Kinetic Energy
    • Event Rate
    • Tungsten
    • Wolfram
    • Brain Slices
    • Slice Preparation
    • Positron Emission Tomography Scans
    • PET Scans
    • Counting Efficiency
    • Linear Energy Transfer
    • Epitaxial Layer
    • Epilayer
    • Dark Chamber
    • Sensitive Layer
    • Energy Spectrum
    • Sensor Surface
    • Efficient Sensor
• authors:
  • Author Name: Truong Nguyen Pham
    Affiliation: CNRS, IPHC, UMR 7178, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37088491628
    ID: 37088491628
    Order: 1
    Author Affiliations:
    • CNRS, IPHC, UMR 7178, Université de Strasbourg, Strasbourg, France
  • Author Name: Patrice Marchand
    Affiliation: CNRS, IPHC, UMR 7178, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37086131112
    ID: 37086131112
    Order: 2
    Author Affiliations:
    • CNRS, IPHC, UMR 7178, Université de Strasbourg, Strasbourg, France
  • Author Name: Christian Finck
    Affiliation: CNRS, IPHC, UMR 7178, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/38018101000
    ID: 38018101000
    Order: 3
    Author Affiliations:
    • CNRS, IPHC, UMR 7178, Université de Strasbourg, Strasbourg, France
  • Author Name: Frederic Boisson
    Affiliation: CNRS, IPHC, UMR 7178, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/38189533900
    ID: 38189533900
    Order: 4
    Author Affiliations:
    • CNRS, IPHC, UMR 7178, Université de Strasbourg, Strasbourg, France
  • Author Name: David Brasse
    Affiliation: CNRS, IPHC, UMR 7178, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37326783600
    ID: 37326783600
    Order: 5
    Author Affiliations:
    • CNRS, IPHC, UMR 7178, Université de Strasbourg, Strasbourg, France
  • Author Name: Patrice Laquerriere
    Affiliation: CNRS, IPHC, UMR 7178, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37086132103
    ID: 37086132103
    Order: 6
    Author Affiliations:
    • CNRS, IPHC, UMR 7178, Université de Strasbourg, Strasbourg, France

Image Sensor

• sensor_type: CMOS Active Pixel Sensor (APS)
• resolution: 960 × 928 pixels
• dynamic_range: 5 orders of magnitude
• pixel_size: 20.7 µm
• dark_current: 15 electrons per pixel in a dark chamber at 20°C

Optical Data

• focal_length: Not specified
• aperture: Not specified
• field_of_view: Not specified
• distortion: Not specified

Performance Metrics

• signal_to_noise_ratio: 57 (after 200 min exposure)
• shutter_speed: 185.6 µs
• noise: 5.0 ± 0.2 counts/s/mm² (high-resistivity layer)

Applications & Benefits

• cell_imaging: Imaging of biological samples such as rose leaves and mouse brain sections for autoradiography.
• benefits: High detection efficiency (44.0 ± 0.5%) and spatial resolution (144 ± 3 µm).

Supporting Organizations

• supported_by: PICSEL Group, CNRS, and other collaborators in the research.

Manuscript Details

• publication_date: Sept. 2020

Relevancy Score

• score: 10

Processed JSON Filename

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