18F Autoradiography Using Pixelated Cmos Technology

• doi: 10.1109/NEWCAS.2017.8010100
• title: 18F autoradiography using pixelated CMOS technology
• publisher: IEEE
• isbn: 978-1-5090-4992-9
• issn:
• rank: 31
• access_type: LOCKED
• content_type: Conferences
• abstract: Autoradiography is a method that allows to take ex-vivo images of thin sections of tissue labelled with a radioactive tracer. In the present work, we aim to study the feasibility of autoradiography with CMOS (Complementary Metal Oxide Semiconductor) Mimosa-28 by using 2-Deoxy-2-18F-fluoro-D-glucose (18F-FDG). Autoradiography allows a functional imaging pixelated with a resolution equivalent to optical microscopy. In this paper, we report the characterisation of the Mimosa-28 sensor. The sensor presents a linearity detection of positrons emitted from 18F with an activity from 450Bq to 3kBq. The detection efficiency was 77.660% ± 0.024% for a source in contact with the sensor. The spatial resolution was 153µm ± 7µm. Mimosa-28 CMOS sensor demonstrates the capability to do autoradiography of a tissue section labelled with 18F-FDG.
• article_number: 8010100
• pdf_url: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8010100
• html_url: https://ieeexplore.ieee.org/document/8010100/
• abstract_url: https://ieeexplore.ieee.org/document/8010100/
• publication_title: 2017 15th IEEE International New Circuits and Systems Conference (NEWCAS)
• conference_location: Strasbourg, France
• conference_dates: 25-28 June 2017
• publication_number: 8001599
• is_number: 8010082
• publication_year: 2017
• publication_date: 25-28 June 2017
• start_page: 41
• end_page: 44
• citing_paper_count: 1
• citing_patent_count: 0
• download_count: 82
• insert_date: 20170814
• index_terms:
  • ieee_terms:
    • Spatial resolution
    • Positrons
    • Photonics
    • Physics
    • Detectors
    • Imaging
  • author_terms:
    • Autoradiography
    • CMOS sensor
    • Fluorine 18
  • dynamic_index_terms:
    • Autoradiography
    • Spatial Resolution
    • Tissue Sections
    • Positron
    • Thin Tissue Sections
    • Point Source
    • Maximum Energy
    • Point Spread Function
    • Epitaxial Layer
    • Epilayer
    • Incident Particle
• isbn_formats:
  • format: Print on Demand(PoD) ISBN, value: 978-1-5090-4992-9, isbnType: New-2005
  • format: Electronic ISBN, value: 978-1-5090-4991-2, isbnType: New-2005
• authors:
  • Author Name: Truong Nguyen Pham
    Affiliation: CNRS IPHC, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37087682622
    ID: 37087682622
    Order: 1
    Author Affiliations:
    • CNRS IPHC, Université de Strasbourg, Strasbourg, France
  • Author Name: Christian Finck
    Affiliation: CNRS IPHC, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/38018101000
    ID: 38018101000
    Order: 2
    Author Affiliations:
    • CNRS IPHC, Université de Strasbourg, Strasbourg, France
  • Author Name: Patrice Marchand
    Affiliation: CNRS IPHC, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37086131112
    ID: 37086131112
    Order: 3
    Author Affiliations:
    • CNRS IPHC, Université de Strasbourg, Strasbourg, France
  • Author Name: David Brasse
    Affiliation: CNRS IPHC, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37326783600
    ID: 37326783600
    Order: 4
    Author Affiliations:
    • CNRS IPHC, Université de Strasbourg, Strasbourg, France
  • Author Name: Frédéric Boisson
    Affiliation: CNRS IPHC, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/38189533900
    ID: 38189533900
    Order: 5
    Author Affiliations:
    • CNRS IPHC, Université de Strasbourg, Strasbourg, France
  • Author Name: Patrice Laquerriere
    Affiliation: CNRS IPHC, Université de Strasbourg, Strasbourg, France
    Author URL: https://ieeexplore.ieee.org/author/37086132103
    ID: 37086132103
    Order: 6
    Author Affiliations:
    • CNRS IPHC, Université de Strasbourg, Strasbourg, France

Image Sensor

• sensor_type: CMOS
• resolution: 2928 x 960
• dynamic_range: not specified
• pixel_size: 20.7 µm
• dark_current: not specified

Optical Data

• focal_length: not specified
• aperture: not specified
• field_of_view: not specified
• distortion: not specified

Performance Metrics

Applications & Benefits

• cell_imaging: The sensor can be used for autoradiography (AR) applications in biomedical imaging.
• benefits: CMOS sensors like Mimosa-28 offer advantages such as improved detection efficiency, higher spatial resolution compared to traditional emulsion films, and the ability to perform functional imaging.

Supporting Organizations

• supported_by: Université de Strasbourg, CNRS, IPHC

Manuscript Details

• publication_date: 25-28 June 2017

Relevancy Score

• score: 8
• missing_fields:
  • dynamic_range
  • dark_current
  • focal_length
  • aperture
  • field_of_view
  • distortion
  • frame_rate
  • signal_to_noise_ratio
  • sensitivity
  • shutter_speed
  • power_consumption
  • noise

Processed JSON Filename

request_852fc7c4-d49f-4da9-867b-68226856058d-18f_autoradiography_using_pixelated_cmos_technology.json